FIGURE 13.4. i and I antigen synthesis.


i and I antigen synthesis. Linear poly-N-acetyllactosamine chains (i antigen) synthesized on N- and O-glycans or glycolipids (R) may be modified by β1–6 N-acetylglucosaminyltransferases (β1–6GlcNAcTs). These enzymes transfer N-acetylglucosamine in β1–6 linkage to internal galactose residues. The newly added β1–6 N-acetylglucosamine branch may serve as substrate for subsequent poly-N-acetyllactosamine biosynthesis (see Figure 13.3). LN designates N-acetyllactosamine unit.

Symbol Key: FIGURE 13.4. i and I antigen synthesis.

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From: Chapter 13, Structures Common to Different Glycans

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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