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The Dynamic Synapse

Molecular Methods in Ionotropic Receptor Biology

Frontiers in Neuroscience

Editors: Josef T Kittler and Stephen J Moss.

Editor Information
Boca Raton (FL): CRC Press/Taylor & Francis; .
ISBN-10: 0-8493-1891-2ISBN-13: 978-0-8493-1891-7

Bringing together the latest information into one easily accessible resource, The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology explores the diverse tools and technologies used to study synaptic processes. Written by world-renowned leaders in the field, the book delineates newly developed techniques, methods, and conceptual advances used for studying neurotransmitter receptors and other synaptic proteins.

A broad array of molecular, biochemical, imaging, and electrophysiological approaches for studying the biology of synapses are described. Specific topics include the use of proteomics to study synaptic protein complexes, the development of phosphorylation state-specific antibodies, post-genomic tools applied to the study of synapses, and RNA interference in neurons. In addition, several chapters focus on methods for gene and protein delivery into neuronal tissue. The use of biochemical, electrophysiological, and optical tagging techniques to study the movement and membrane trafficking of neurotransmitter receptors in the membranes of live nerve cells are also discussed. To complement these approaches, the application of state-of-the-art approaches for achieving long-term alterations in the genetic complement of neurons in vivo using viral vectors or homologous recombinations of ES cells is also described.


Series editors: Sidney A Simon and Miguel AL Nicolelis

This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use.

Copyright © 2006, Taylor & Francis Group, LLC.
Bookshelf ID: NBK1843PMID: 21204469


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