Table 12Statistical summary of test performance characteristics based on the manufacturer, optimum, and lowest cutpoints in the emergency department

TestCutpointAssay typeN studySensitivitySpecificityLR+LR-log DORAUC
Est95% CII2Est95% CII2Est95% CII2Est95% CII2Est95% CII2Est95% CI
ED-BNPManufacturerA10.860.76, 0.93-0.980.85, 1.00-39.13.59, 426-0.140.07, 0.30-5.613.03, 8.19---
B30.950.93, 0.9725.80.610.49, 0.7287.32.431.75, 3.3789.90.090.04, 0.1772.63.362.38, 4.3482.5--
C10.960.94, 0.97-0.620.59, 0.65-2.512.32, 2.71-0.070.05, 0.10-3.563.14, 3.98---
D170.950.93, 0.9784.90.620.53, 0.7096.92.712.16, 3.4095.90.090.07, 0.1372.13.563.10, 4.0381.60.920.90, 0.95
All*220.950.93, 0.9681.30.630.57, 0.7096.72.642.23, 3.1294.70.090.07, 0.1272.13.553.18, 3.9279.40.920.90, 0.94
OptimumA20.810.51, 1.0092.90.920.85, 1.0022.29.342.12, 41.261.10.150.01, 1.5991.44.230.80, 7.6686.6--
B40.880.80, 0.9691.40.780.72, 0.8577.13.93.22, 4.7140.60.140.07, 0.2789.53.412.86, 3.9767.90.910.88, 0.95
C10.960.94, 0.97-0.620.59, 0.65-2.512.32, 2.71-0.070.05, 0.11-3.563.14, 3.98---
D220.90.87, 0.93910.770.71, 0.8396.14.453.30, 6.0296.50.140.11, 0.1884.33.673.27, 4.0884.80.930.91, 0.95
All290.90.88, 0.9290.40.780.72, 0.8396.34.33.45, 5.3595.50.140.11, 0.1786.83.63.28, 3.9282.10.920.91, 0.94
LowestA20.810.51, 1.0092.90.920.85, 1.0022.29.342.12, 41.261.10.150.01, 1.5991.44.230.80, 7.6686.6--
B40.940.92, 0.9755.40.640.55, 0.73852.61.96, 3.4687.20.10.06, 0.1769.53.322.63, 4.0174.50.910.87, 0.95
C20.960.94, 0.981.10.620.59, 0.6502.52.32, 2.6900.070.05, 0.1003.573.16, 3.990--
D230.940.92, 0.9691.70.620.52, 0.7198.22.672.17, 3.2997.20.090.06, 0.1488.73.53.06, 3.9481.10.920.89, 0.94
All310.940.92, 0.9690.70.640.56, 0.7197.82.712.28, 3.2196.80.10.07, 0.1488.63.473.12, 3.8179.30.920.90, 0.94
ED-NT-proBNPManufacturerE40.90.87, 0.9446.80.650.44, 0.8695.82.721.27, 5.8297.10.160.11, 0.2555.12.791.79, 3.7985.30.870.79, 0.95
OptimumE190.880.84, 0.9290.70.730.65, 0.8296.53.592.46, 5.2397.50.170.13, 0.2281.33.162.73, 3.5980.70.900.87, 0.93
LowestE190.930.91, 0.9590.40.550.42, 0.6898.32.261.71, 2.9998.50.120.08, 0.2087.63.082.56, 3.5878.40.890.86, 0.93

NOTE: AUC was calculated for the group with 4 or more studies

ASSAY: A-ADVIA -Centaur® BNP Assay, B-Abbott AxSYM® B-Type, C-TRIAGE -B-Type Beckman, D-TRIAGE -B-Type Test, E-ELECSYS -proBNP Immunoassay

*

Sanz 2006 counted twice for using ADVIA and TRIAGE B-type assay

Abbreviations: AUC = area under the curve; CI = confidence interval; DOR = diagnostic odds ratio; ED = emergency department; Est = estimate; LR- = negative likelihood ratio; LR+ = positive likelihood ratio; n=sample size; PC= primary care

From: Results

Cover of Use of Natriuretic Peptide Measurement in the Management of Heart Failure
Use of Natriuretic Peptide Measurement in the Management of Heart Failure [Internet].
Comparative Effectiveness Reviews, No. 126.
Balion C, Don-Wauchope A, Hill S, et al.

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