Table 38Numbers of studies and subjects, strength of evidence domains, magnitude of effect, and strength of evidence among studies comparing surgical interventions with compression systems alone in terms of wound healing or wound recurrence

Comparison / Outcome*Number of Studies (Participants)Domains Pertaining to Strength of EvidenceStrength of Evidence
Risk of BiasConsistencyDirectnessPrecision
Superficial vein surgery vs. compression alone / wound healing1 RCT (500); 1 cohort (669)MediumConsistentDirectPreciseNo effect
Moderate SOE
CHIVA vs. compression alone / wound healing1 RCT (47)LowNADirectImpreciseNo effect
Low SOE
SEPS vs. compression alone / wound healing2 RCTs (246)LowConsistentDirectPreciseNo effect
High SOE
Sclerotherapy vs. compression alone / wound healing1 RCT (40)
2 cohorts (188)
HighInconsistentDirectImpreciseUnclear effect
Insufficient SOE
Superficial vein surgery vs. compression alone / wound recurrence1 RCT (500); 1 cohort (669)MediumConsistentDirectPreciseSmall effect
Moderate SOE
CHIVA vs. compression alone / wound recurrence1 RCT (47)LowNADirectImpreciseSmall effect
Low SOE
SEPS vs. compression alone / wound recurrence1 RCT (170)LowNADirectPreciseNo effect
High SOE
Sclerotherapy vs. compression alone / wound recurrence1 cohort (118)HighNADirectImpreciseUnclear effect
Insufficient SOE

CHIVA = Conservative Hemodynamic treatment of Insufficiency of the Venous system in an Ambulatory setting; EVLT = endovenous laser therapy; NA = not applicable; RFA = radiofrequency ablation; SEPS = subfascial endoscopic perforator surgery; SOE = strength of evidence; vs. = versus

*

The strength of evidence for all comparisons not listed here were graded as insufficient because we did not find any studies addressing them.

We defined the strength of evidence as follows: High = High confidence that the evidence reflects the true effect. Further research is unlikely to change our confidence in the estimate of the effect. Moderate = Moderate confidence that the evidence reflects the true effect. Further research may change our confidence in the estimate of the effect and may change the estimate. Low = Low confidence that the evidence reflects the true effect. Further research is likely to change our confidence in the estimate of the effect and is likely to change the estimate. Insufficient = Evidence is unavailable or does not permit a conclusion.

From: Results

Cover of Chronic Venous Ulcers: A Comparative Effectiveness Review of Treatment Modalities
Chronic Venous Ulcers: A Comparative Effectiveness Review of Treatment Modalities [Internet].
Comparative Effectiveness Reviews, No. 127.
Zenilman J, Valle MF, Malas MB, et al.

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