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Optimal Warfarin Management for the Prevention of Thromboembolic Events in Patients with Atrial Fibrillation: A Systematic Review of the Clinical Evidence [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2011 Nov. (CADTH Optimal Use Report, No. 1.2A.)

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Optimal Warfarin Management for the Prevention of Thromboembolic Events in Patients with Atrial Fibrillation: A Systematic Review of the Clinical Evidence [Internet].

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4KEY FINDINGS

  • Specialized anticoagulation services improve TTR compared with UC.
  • Improvement of TTR within the included studies did not necessarily translate into a reduction in hemorrhage, thromboembolism, or need for additional medical care.
  • The evidence available that compares different specialized models of care or service components is limited in both quantity and quality.
  • The effect of PST or PSM on TTR was mixed, with studies showing either improved TTR with PST/PSM (patient self-testing alone or in combination with patient self-management) or no difference between models of care.
  • Effects on clinical outcomes were also mixed, but PST/PSM generally resulted in lower mortality rates and reduced incidence of thromboembolism.
  • PST/PSM did not affect the rate of bleeding events.
  • PST/PSM may improve quality of life and patient satisfaction.
Copyright © 2011 CADTH.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK169499

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