Figure 11. (A) Viral IE (ICP4, ICP27, ICP22) and control (S15, Sp1, TBP) mRNA levels in HFF cells treated with DMSO or the indicated concentrations of ML324 for 3 hrs and infected with HSV-1 (0.

Figure 11

(A) Viral IE (ICP4, ICP27, ICP22) and control (S15, Sp1, TBP) mRNA levels in HFF cells treated with DMSO or the indicated concentrations of ML324 for 3 hrs and infected with HSV-1 (0.1 pfu/cell) for 3 hr. (B) Viral yields from HFF cells treated with DMSO or ML324 for 3 hr and infected with HSV-1 (0.1 pfu/cell) for 24 hr in the presence of the drugs.

From: Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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