Table 8In vitro ADME profile for probe ML321 and a relative analog NCGC00109414 (CID16007814)

Results showed compound ML321 has good stability and permeability.

CompoundAqueous Kinetic SolubilityLiver Microsomal Stability (T1/2 in min)Plasma Stability (% remaining after 2 h)Caco-2 Permeability (10−6, cm/s)
μg/mLμMMouseHumanMouseHumanPapp (A-B)Papp (B-A)
ML32146.5113.324.726.495.298.418.823.8
CID1600781411.526.435.9N/AN/AN/A21.616.2

From: Discovery, optimization, and characterization of a novel series of dopamine D2 versus D3 receptor selective antagonists

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