NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

High-Sensitivity Cardiac Troponin for the Rapid Diagnosis of Acute Coronary Syndrome in the Emergency Department: A Clinical and Cost-Effectiveness Evaluation [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2013 Mar. (CADTH Optimal Use Report, No. 2.1A.)

Cover of High-Sensitivity Cardiac Troponin for the Rapid Diagnosis of Acute Coronary Syndrome in the Emergency Department: A Clinical and Cost-Effectiveness Evaluation

High-Sensitivity Cardiac Troponin for the Rapid Diagnosis of Acute Coronary Syndrome in the Emergency Department: A Clinical and Cost-Effectiveness Evaluation [Internet].

Show details

APPENDIX 1LITERATURE SEARCH STRATEGY

OVERVIEW
Interface:Ovid
Databases:Embase
Ovid MEDLINE
Ovid MEDLINE In-Process & Other Non-Indexed Citations
Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:May 16, 2012
Alerts:Monthly search updates began May 16, 2012 and ran until March 11, 2013.
Study Types:Systematic reviews; meta-analyses; technology assessments; randomized controlled trials; non-randomized controlled clinical trials; comparative studies; economic evaluations.
Limits:English
Humans (for clinical studies)
SYNTAX GUIDE
/At the end of a phrase, searches the phrase as a subject heading
expExplode a subject heading
*Before a word, indicates that the marked subject heading is a primary topic; or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
#Truncation symbol for one character
?Truncation symbol for one or no characters only
ADJRequires words are adjacent to each other (in any order)
ADJ#Adjacency within # number of words (in any order)
.tiTitle
.abAbstract
.dmEmbase=Device Manufacturer; contains the full name of the manufacturer of a drug or device discussed in an article
.dvEmbase=Device Trade Name; contains the medical device trade names assigned to the records
.hwHeading Word; usually includes subject headings and controlled vocabulary
.jwJournal Word; contains individual words from every journal name
.kwMedline=Keyword Heading; contains the Keyword Headings assigned by indexers at NLM to describe the content of an article
Embase=Key Word; contains keywords defined by the author of the article
.mpMedline=title, abstract, original title, name of substance word, subject heading word, protocol supplementary concept, rare disease supplementary concept, unique identifier
Embase=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword
.ptPublication type
MULTI-DATABASE STRATEGY
Line #Searches
Medical Emergency Circumstances, Acute Myocardial Infarction, Cardiac Ischemia, Chest Pain, or Acute Coronary Syndrome Concept
1exp Ambulances/ use prmz
2Early Diagnosis/ use prmz
3Emergencies/ use prmz
4Emergency Medical Services/ use prmz
5Emergency Medical Technicians/ use prmz
6Emergency Medicine/ use prmz
7exp Emergency Service, Hospital/ use prmz
8exp Emergency Treatment/ use prmz
9Evidence-Based Emergency Medicine/ use prmz
10Time Factors/ use prmz
11Triage/ use prmz
12((acute or urgent*) adj2 care).ti,ab,kw.
13(ambulance* or emergencies or emergency* or first response or first responder* or out-of-hospital or paramedic* or prehospital or pre-hospital).ti,ab,kw.
14(earl* or rapid*).ti.
15((earl* or rapid*) adj (diagnos* or detect*)).ab,kw.
16(trauma center* or trauma centre* or triage or rescue personnel).ti,ab,kw.
17Ambulance/ use emez
18Early Diagnosis/ use emez
19Emergency/ use emez
20Emergency Care/ use emez
21Emergency Health Service/ use emez
22Emergency Medicine/ use emez
23Emergency Medical Services Education/ use emez
24Emergency Nurse Practitioner/ use emez
25Emergency Nursing/ use emez
26Emergency Patient/ use emez
27Emergency Physician/ use emez
28Emergency Surgery/ use emez
29Emergency Treatment/ use emez
30Emergency Ward/ use emez
31Evidence Based Emergency Medicine/ use emez
32First Aid/ use emez
33Rescue Personnel/ use emez
34Time/ use emez
35Acute Coronary Syndrome/ use prmz
36(Chest Pain/ or Heart Failure/ or Heart Injuries/ or Myocardial Infarction/) and acute*.mp.
37((coronary syndrome? or (heart adj2 infarct*) or (myocardial adj2 infarct*) or (myocardium adj2 infarct*) or chest pain?) and acute*).ti,ab,kw.
38((cardiac* or myocardial injur*) and acute*).ti.
39Acute Coronary Syndrome/ use emez
40Acute Heart Failure/ use emez
41Acute Heart Infarction/ use emez
42(Heart Failure/ or Heart Infarction/ or exp Heart Injury/ or Thorax Pain/) and acute*.mp.
43or/1-42
High-Sensitivity Cardiac CTn Concept
44Troponin/
45Troponin I/
46Troponin T/
47(troponin* or cTn* or TnI* or TnT*).ti,ab,kw,dm,dv.
48or/44-47
49(high sensitivity or highsensitivity or high sensitive or highsensitive or HS or highly sensitive or highlysensitive or ultra high* or ultrahigh* or ultra sensitiv* or ultrasensitiv* or new assay* or newer assay* or emerging assay* or new sensitive or increased sensitivity or next generation or new generation or newer generation or better sensitivity).ti,ab,kw,dm,dv.
50more sensitiv*.ti,ab,kw,dm,dv.
51or/49-50
5248 and 51
53(cTnIhs* or cTnI-hs* or cTnIultra* or cTnI-ultra* or TnIultra* or TnI-ultra* or hs-cTnI* or hs-TnI* or hscTnI* or hs-cTnI*).ti,ab,kw,dv.
54(cTnThs* or cTnT-hs* or cTnTultra* or cTnT-ultra* or hs-cTnT* or hs-TnT* or hs-cTnT* or hs-cTnT*).ti,ab,kw,dv.
55(Architect* adj10 (troponin* or cTn* or TnI* or TnT*)).ti,ab,kw,dm,dv.
56(Access* and Beckman* and (AccuTnI* or troponin* or cTn* or TnI* or TnT*)).ti,ab,kw,dm,dv.
57(Vista* and (troponin* or cTn* or TnI* or TnT*)).ti,ab,kw,dm,dv.
58((Cobas e601 or Cobas e411 or Elecsys) adj10 (troponin* or cTn* or TnI* or TnT*)).ti,ab,kw,dm,dv.
59or/52-58
Clinical Studies
60(Randomized Controlled Trial or Controlled Clinical Trial).pt.
61(Clinical Trial or Clinical Trial, Phase II or Clinical Trial, Phase III or Clinical Trial, Phase IV).pt.
62Multicenter Study.pt.
63Randomized Controlled Trial/
64Randomized Controlled Trials as Topic/
65Controlled Clinical Trial/
66Controlled Clinical Trials as Topic/
67Clinical Trial/ or Phase 2 Clinical Trial/ or Phase 3 Clinical Trial/ or Phase 4 Clinical Trial/
68Clinical Trials as Topic/ or Clinical Trials, Phase II as Topic/ or Clinical Trials, Phase III as Topic/ or Clinical Trials, Phase IV as Topic/
69Clinical Trials/
70Multicenter Study/ or Multicenter Study as Topic/
71Randomization/
72Random Allocation/
73Random Sampling/
74Double-Blind Method/
75Double Blind Procedure/
76Double-Blind Studies/
77Single-Blind Method/
78Single Blind Procedure/
79Single-Blind Studies/
80Placebos/
81Placebo/
82Control Groups/
83Control Group/
84Cross-Over Studies/ or Crossover Procedure/
85(random* or sham or placebo*).ti,ab,hw.
86((singl* or doubl*) adj (blind* or dumm* or mask*)).ti,ab,hw.
87((tripl* or trebl*) adj (blind* or dumm* or mask*)).ti,ab,hw.
88(control* adj3 (study or studies or trial*)).ti,ab,hw.
89(clinical adj3 (study or studies or trial*)).ti,ab,hw.
90(non-random* or nonrandom* or quasi-random* or quasirandom*).ti,ab,hw.
91(phase adj3 (study or studies or trial*)).ti,ab,hw.
92((crossover or cross-over) adj3 (study or studies or trial*)).ti,ab,hw.
93((multicent* or multi-cent*) adj3 (study or studies or trial*)).ti,ab,hw.
94(allocated adj "to").ti,ab,hw.
95trial.ti.
96Epidemiologic Methods/
97Epidemiologic Studies/
98Cohort Studies/
99Longitudinal Studies/
100Prospective Studies/
101Follow-Up Studies/
102Retrospective Studies/
103Case-Control Studies/
104Cross-Sectional Study/
105Evaluation Studies.pt.
106Evaluation Studies as Topic/
107Comparative Study.pt.
108Observational Study/
109Cohort Analysis/
110exp Case Control Study/
111Cross-sectional Study/
112Quasi Experimental Study/
113exp Longitudinal Studies/
114Prospective Studies/
115Retrospective Studies/
116Followup Studies/
117Pretesting/
118exp Program Evaluation/
119(observational adj3 (study or studies or design or analysis or analyses)).ti,ab,hw.
120(cohort adj7 (study or studies or design or analysis or analyses)).ti,ab,hw.
121(prospective adj7 (study or studies or design or analysis or analyses or cohort)).ti,ab,hw.
122((follow up or followup) adj7 (study or studies or design or analysis or analyses)).ti,ab,hw.
123((longitudinal or longterm or (long adj term)) adj7 (study or studies or design or analysis or analyses or data or cohort)).ti,ab,hw.
124(retrospective adj7 (study or studies or design or analysis or analyses or cohort or data or review)).ti,ab,hw.
125((case adj control) or (case adj comparison) or (case adj controlled)).ti,ab,hw.
126(case-referent adj3 (study or studies or design or analysis or analyses)).ti,ab,hw.
127(population adj3 (study or studies or analysis or analyses)).ti,ab,hw.
128((multidimensional or (multi adj dimensional)) adj3 (study or studies or design or analysis or analyses)).ti,ab,hw.
129(cross adj sectional adj7 (study or studies or design or research or analysis or analyses or survey or findings)).ti,ab,hw.
130((natural adj experiment) or (natural adj experiments)).ti,ab,hw.
131(quasi adj (experiment or experiments or experimental)).ti,ab,hw.
132((non experiment or nonexperiment or non experimental or nonexperimental) adj3 (study or studies or design or analysis or analyses)).ti,ab,hw.
133(prevalence adj3 (study or studies or analysis or analyses)).ti,ab,hw.
134((comparison or comparative*) adj3 (study or studies or analysis or analyses)).ti,ab,hw.
135((before-after or (before* adj after)) adj3 (study or studies or design?)).mp.
136((follow up or followup) and (base line* or baseline*)).ti,ab,hw.
137exp "Sensitivity and Specificity"/
138False Positive Reactions/
139False Negative Reactions/
140Diagnostic Techniques, Cardiovascular/
141Troponin/du
142Troponin T/du
143Troponin I/du
144Validation Studies.pt.
145sensitivit*.ti,ab.
146specificity.ti,ab.
147predict*.ti,ab.
148distinguish*.ti,ab.
149differentiat*.ti,ab.
150enhancement.ti,ab.
151identif*.ti,ab.
152detect*.ti,ab.
153diagnos*.ti,ab.
154accura*.ti,ab.
155precision.ti,ab.
156prognos*.ti,ab.
157false positive*.ti,ab.
158false negative*.ti,ab.
159exp Diagnosis/
160Diagnostic Procedures/
161Acute Coronary Syndrome/di or Acute Heart Failure/di or Acute Heart Infarction/di or Chest Pain/di or Heart Failure/di or Heart Infarction/di or Heart Injury/di or Heart Injuries/ or Myocardial Infarction/di or Thorax Pain/di
162or/60-161
163exp animals/
164exp animal experimentation/
165exp models animal/
166exp animal experiment/
167nonhuman/
168or/163-167
169exp humans/
170exp human experiment/
171or/169-170
172168 not 171
17343 and 59 and 162
174173 not 172
175Diagnostic Techniques, Cardiovascular/
176biomarker*.ti.
177Cardiovascular System Examination/
178or/175-177
179Meta-Analysis.pt.
180Meta-Analysis/ or Systematic Review/ or Meta-Analysis as Topic/ or exp Technology Assessment, Biomedical/
181((systematic* adj3 (review* or overview*)) or (methodologic* adj3 (review* or overview*))).ti,ab.
182((quantitative adj3 (review* or overview* or synthes*)) or (research adj3 (integrati* or overview*))).ti,ab.
183((integrative adj3 (review* or overview*)) or (collaborative adj3 (review* or overview*)) or (pool* adj3 analy*)).ti,ab.
184(data synthes* or data extraction* or data abstraction*).ti,ab.
185(handsearch* or hand search*).ti,ab.
186(mantel haenszel or peto or der simonian or dersimonian or fixed effect* or latin square*).ti,ab.
187(met analy* or metanaly* or health technology assessment* or HTA or HTAs).ti,ab.
188(meta regression* or metaregression* or mega regression*).ti,ab.
189(meta-analy* or metaanaly* or systematic review* or biomedical technology assessment* or bio-medical technology assessment*).mp,hw.
190(medline or Cochrane or pubmed or medlars).ti,ab,hw.
191(cochrane or health technology assessment or evidence report).jw.
192Meta Analysis/ or Systematic Review/ or Biomedical Technology Assessment/
193or/179-192
19443 and (59 or 178) and 193
195174 or 194
196limit 195 to English
197remove duplicates from 196
Economic Studies
198*Economics/
199*Economics, Medical/
200*Economics, Pharmaceutical/
201exp "Costs and Cost Analysis"/
202exp Health Care Costs/
203exp Decision Support Techniques/
204Economic Value of Life/
205exp Models, Economic/
206Markov Chains/
207Monte Carlo Method/
208Decision Trees/
209Uncertainty/
210exp "Quality of Life"/
211Quality-Adjusted Life Years/
212exp Health Care Cost/
213exp Health Economics/
214exp Economic Evaluation/
215exp Pharmacoeconomics/
216exp Economic Aspect/
217Quality Adjusted Life Year/
218(econom* or cost or costly or costing or costed or price or prices or pricing or priced or discount or discounts or discounted or discounting or expenditure or expenditures or budget* or afford* or pharmacoeconomic or pharmaco-economic*).ti,ab.
219(cost* adj1 (util* or effective* or efficac* or benefit* or consequence* or analy* or minimi* or saving* or breakdown or lowering or estimate* or variable* or allocation or control or illness or sharing or life or lives or affordabl* or instrument* or technolog* or day* or fee or fees or charge or charges)).ti,ab.
220(decision adj1 (tree* or analy* or model*)).ti,ab.
221((value or values or valuation) adj2 (money or monetary or life or lives or costs)).ti,ab.
222(qol or qoly or qolys or hrqol or qaly or qalys or qale or qales).ti,ab.
223(sensitivity analys*s or "willingness to pay" or quality-adjusted life year* or quality adjusted life year* or quality-adjusted life expectanc* or quality adjusted life expectanc*).ti,ab.
224(unit-cost or unit-costs or markov).ti,ab.
225or/198-224
22643 and (59 or 178) and 225
227limit 226 to English
228remove duplicates from 227
OTHER DATABASES
PubMedSame MeSH, keywords, limits, and study types used as per MEDLINE search, with appropriate syntax used.
The Cochrane Library
Issue 2–3, 2012
Same MeSH and keywords, used as per Medline search, excluding study types, Human, and language restrictions. Syntax adjusted for Cochrane Library databases.
Health Economic Evaluations Database (HEED)Same keywords used as per Medline search, excluding study types, Human, and language restrictions. Syntax adjusted for HEED.

Grey Literature

Dates for Search:June 2012; focused update March 11, 2013
Keywords:Included terms for high-sensitivity cardiac troponin
Limits:English (with the exception of French Canadian technology assessments which are not translated)

The following sections of the CADTH grey literature checklist, “Grey matters: a practical tool for evidence-based searching” (http://www.cadth.ca/resources/grey-matters) were searched:

  • Health Technology Assessment Agencies
  • Health Economic
  • Databases (free)
  • Internet Search
  • Open Access Journals.

Conferences and Meetings

  1. American Association for Clinical Chemistry Annual Meeting Abstracts:
  2. Canadian Society of Clinical Chemists Annual Conference:
  3. International Federation of Clinical Chemistry and Laboratory Medicine, IFCC-WorldLab & IFCC EuroMedLab Congresses:
  4. American Heart Association (AHA):
Copyright © 2013 Canadian Agency for Drugs and Technologies in Health.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK168942

Views

  • PubReader
  • Print View
  • Cite this Page
  • PDF version of this title (2.8M)

Other titles in this collection

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...