NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Neurodegeneration: Exploring Commonalities Across Diseases is the summary of a workshop hosted by the Institute of Medicine's (IOM's) Forum on Neuroscience and Nervous System Disorders in Spring 2012 to explore commonalities across neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Participants from academia; pharmaceutical and biotechnology industries; government agencies such as the National Institutes of Health and the U.S. Department of Veterans Affairs (VA); patient advocacy groups; and private foundations presented and identified potential opportunities for collaboration across the respective research and development communities. This report identifies and discusses commonalities related to genetic and cellular mechanisms, identifies areas of fundamental science needed to facilitate therapeutics development, and explores areas of potential collaboration among the respective research communities.
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, ALS, and FTD, are becoming increasingly prevalent in the United States due to an aging population. Implications are grave for quality of life and health care costs. Research on neurodegenerative diseases has expanded greatly over the past four decades. Nevertheless, fundamental questions remain about the biology of these diseases, and further insights into the mechanisms of these diseases would help to inform the development of effective means to prevent and to efficiently treat them. Recent findings have revealed certain commonalities in genetic and cellular mechanisms across neurodegenerative diseases. These findings suggest that it might be valuable - at least in some cases - to change the traditional way of studying these diseases by no longer seeing each as an independent entity, but rather as clinical variants of common cellular and molecular biological defects. This approach could help enhance basic scientific understanding of neurodegenerative disease, and could help with the development of biomarkers and new therapeutics.
Contents
- THE NATIONAL ACADEMIES
- PLANNING COMMITTEE ON NEURODEGENERATION: OPPORTUNITIES FOR COLLABORATION ACROSS DISEASESPECIFIC RESEARCH AND DEVELOPMENT COMMUNITIES
- FORUM ON NEUROSCIENCE AND NERVOUS SYSTEM DISORDERS
- Reviewers
- 1. Introduction
- 2. Rationale for Exploring Commonalities Across Neurodegenerative Diseases
- 3. Protein Aggregation
- 4. Transmissibility
- 5. Mitochondrial Pathology
- 6. Errors in RNA
- RNA GAIN OF FUNCTION MECHANISMS IN NEUROGENERATIVE DISEASE: MICROSATELLITE EXPANSION DISORDERS
- EMERGING ROLES OF NON-CODING RNA NETWORKS IN THE PATHOGENESIS OF NEURODEGENERATIVE DISEASE
- ANTISENSE OLIGONUCLEOTIDES AS THERAPIES FOR RNA-BINDING PROTEIN ERRORS
- RESEARCH NEEDS AND NEXT STEPS SUGGESTED BY INDIVIDUAL PARTICIPANTS
- 7. Closing Remarks
- APPENDIXES
Rapporteurs: Miriam Davis and Clare Stroud.
This project was supported by contracts between the National Academy of Sciences and the Alzheimer's Association; CeNeRx Biopharma; the Department of Health and Human Services' National Institutes of Health (NIH, Contract No. N01-OD-4-2139) through the National Eye Institute, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, and NIH Blueprint for Neuroscience Research; Department of Veterans Affairs; Eli Lilly and Company; Fast Forward, LLC; Foundation for the National Institutes of Health; GE Healthcare, Inc.; GlaxoSmithKline, Inc.; Johnson & Johnson Pharmaceutical Research and Development, LLC; Lundbeck Research USA; Merck Research Laboratories; The Michael J. Fox Foundation for Parkinson's Research; the National Science Foundation (Contract No. OIA-0753701); One Mind for Research; Pfizer Inc.; the Society for Neuroscience; and Wellcome Trust. The views presented in this publication do not necessarily reflect the view of the organizations or agencies that provided support for this project.
Suggested citation:
IOM (Institute of Medicine). 2013. Neurodegeneration: Exploring commonalities across diseases: Workshop summary. Washington, DC: The National Academies Press.
NOTICE: The workshop that is the subject of this workshop summary was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.
- NLM CatalogRelated NLM Catalog Entries
- Review Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders.[Am J Neurodegener Dis. 2013]Review Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders.Ramanan VK, Saykin AJ. Am J Neurodegener Dis. 2013 Sep 18; 2(3):145-75. Epub 2013 Sep 18.
- Prevalence of amyotrophic lateral sclerosis - United States, 2010-2011.[MMWR Suppl. 2014]Prevalence of amyotrophic lateral sclerosis - United States, 2010-2011.Mehta P, Antao V, Kaye W, Sanchez M, Williamson D, Bryan L, Muravov O, Horton K, Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, Centers for Disease Control and Prevention (CDC). MMWR Suppl. 2014 Jul 25; 63(7):1-14.
- Review Future Opportunities to Leverage the Alzheimer’s Disease Neuroimaging Initiative: Workshop Summary[ 2011]Review Future Opportunities to Leverage the Alzheimer’s Disease Neuroimaging Initiative: Workshop SummaryInstitute of Medicine (US) Forum on Neuroscience and Nervous System Disorders. 2011
- Review Modeling neurodegenerative diseases in Caenorhabditis elegans.[Exp Neurol. 2013]Review Modeling neurodegenerative diseases in Caenorhabditis elegans.Li J, Le W. Exp Neurol. 2013 Dec; 250:94-103. Epub 2013 Oct 2.
- Review Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis.[Proteins. 2013]Review Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis.Mulligan VK, Chakrabartty A. Proteins. 2013 Aug; 81(8):1285-303. Epub 2013 Jul 2.
- NeurodegenerationNeurodegeneration
Your browsing activity is empty.
Activity recording is turned off.
See more...