Table 1

Cellular proteins that bind to the HCV core protein. The list contains cellular proteins with various cellular functions that interact with HCV core. The interaction of HCV core with these cellular proteins may have pathogenic implications. Please refer to the text for details.

Core-Interacting proteinFunctionReference
Apolipoprotein AIIlipid metabolismSabile et al., 1999; Shi et al., 2002
CAP-RfRNA helicaseYou et al., 1999
complement receptor gC1qRT-cell responseKittlesen et al., 2000
cyclin-dependent kinase 7cell cycleOhkawa et al., 2004
DEAD box proteinRNA helicaseMamiya and Worman, 1999
DEAD box protein 3RNA helicaseOwsianka and Patel, 1999
heterogeneous nuclear ribonucleoprotein Ktranscriptional controlHsieh et al., 1998
JAK1/2signal transductionHosui et al., 2003
lymphotoxin-β receptorcytotoxicityChen et al., 1997
p53transcriptional controlOtsuka et al., 2000
p73transcriptional controlAlisi et al., 2003
proteasome activator PA28γprotein stabilityMoriishi et al., 2003
retinoid X receptor αtranscriptional controlTsutsumi et al., 2002
Smad3transcriptional controlCheng et al., 2004
Sp110btranscriptional controlWatashi et al., 2003
STAT3cell transformationYoshida et al., 2002
TAFII28transcriptional controlOtsuka et al., 2000
Tumor necrosis factor receptor 1apoptosisZhu et al., 2001
14-3-3 proteinsignal transductionAoki et al., 2000

From: Chapter 3, Assemble and Interact: Pleiotropic Functions of the HCV Core Protein

Cover of Hepatitis C Viruses
Hepatitis C Viruses: Genomes and Molecular Biology.
Tan SL, editor.
Norfolk (UK): Horizon Bioscience; 2006.
Copyright © 2006, Horizon Bioscience.

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