Fig. 2. Cis-acting RNA replication regulatory elements in the NS5B-coding region that interact with the 3′UTR (represented by the HCV-Con1 strain).

Fig. 2

Cis-acting RNA replication regulatory elements in the NS5B-coding region that interact with the 3′UTR (represented by the HCV-Con1 strain). (A) The cruciform structure formed at the end of the NS5B-coding sequence contains 5BSL3.1, 5BSL3.2, and 5BSL3.3, among which 5BSL3.2 is required for HCV RNA replication (You et al., 2004). (B) Kissing-loop interaction between the loop sequences of 5BSL3.2 and SL2 of the X region (Friebe et al., 2005).

From: Chapter 2, HCV 5′ and 3′UTR: When Translation Meets Replication

Cover of Hepatitis C Viruses
Hepatitis C Viruses: Genomes and Molecular Biology.
Tan SL, editor.
Norfolk (UK): Horizon Bioscience; 2006.
Copyright © 2006, Horizon Bioscience.

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