Fig. 1. Schematic diagram of the NS5A protein.

Fig. 1

Schematic diagram of the NS5A protein. Several prominent features of the NS5A protein and described in detail in this review are shown. The three domain structure of NS5A (Tellinghuisen et al., 2005) is depicted. The N-terminal amphipathic α-helix (Elazar et al., 2003; Penin et al., 2004), the IFN sensitivity determining region (ISDR) (Tan and Katze, 2001), the class I and class II proline-rich (Tan et al., 1999), and NLS sequences (Ide et al., 1996) are also shown. In addition, basal and hyperphosphorylation sites as well as the binding sites for several interacting proteins (see Table 1) are noted.

From: Chapter 9, HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication

Cover of Hepatitis C Viruses
Hepatitis C Viruses: Genomes and Molecular Biology.
Tan SL, editor.
Norfolk (UK): Horizon Bioscience; 2006.
Copyright © 2006, Horizon Bioscience.

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