Fig. 3. Key residues in HCV helicase.

Fig. 3

Key residues in HCV helicase. (A) HCV helicase residues likely involved in modulating ATP binding and hydrolysis. The approximate position of ATP bound to HCV helicase is revealed by a structural alignment of HCV helicase (PDB file 1A1V) (Kim et al., 1998) with the SF2 helicase RecQ bound to ATPγS (PDB file 1OYY) (Bernstein et al., 2003) (B) Key residues contacting the oligonucleotide bound to HCV helicase in PDB file 1A1V (Kim et al., 1998).

From: Chapter 7, HCV Helicase: Structure, Function, and Inhibition

Cover of Hepatitis C Viruses
Hepatitis C Viruses: Genomes and Molecular Biology.
Tan SL, editor.
Norfolk (UK): Horizon Bioscience; 2006.
Copyright © 2006, Horizon Bioscience.

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