An illustration of the genomic differences it the subspecies level for P. acnes

FIGURE WO-26Genomic differences at the subspecies level (P. acnes)

Genome comparison of 71 P. acnes strains shows that the genomes of RT4 and RT5 are distinct from others. Two chromosomal regions, loci 1 and 2, are unique to clade IA-2 and one other genome HL086PA1. Clade IA-2 consists of mainly RT4 and RT5 that are highly enriched in acne. The presence of a plasmid (locus 3) is also characteristic of RT4 and RT5. Each row represents a P. acnes genome colored according to the ribotypes. Rows are ordered by the phylogeny calculated based on the SNPs in P. acnes core genome. Only the topology is shown. The clades were named based on their recA types (IA, IB, and II). Columns represent 16 predicted open reading frames (ORFs) in the genomes and are ordered by ORF positions along the finished genome HL096PA1, which encodes a 55 Kb plasmid. Only the first 300 ORFs on the chromosome (on the left) and all the ORFs on the plasmid (on the right) are shown. The colored plasmid regions represent genes on contigs that match exclusively to the HL096PA1 plasmid region. The genes that fall on contigs that clearly extend beyond the plasmid region are likely to be chromosomally located and are colored in grey. Acne index for the ribotypes was calculated based on the percentage of clones of each ribotype found in acne.

SOURCE: Fitz-Gibbon et al. (2013). Reprinted by permission from Macmillan Publishers Ltd: [JOURNAL OF INVESTIGATIVE DERMATOLOGY] (Fitz-Gibbon et al., 2013), copyright (2013).

From: Workshop Overview

Cover of The Science and Applications of Microbial Genomics
The Science and Applications of Microbial Genomics: Workshop Summary.
Institute of Medicine (US) Forum on Microbial Threats.
Washington (DC): National Academies Press (US); 2013.
Copyright © 2013, National Academy of Sciences.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.