Figure 2.11. Dose-response lines from a variety of animal experiments.

Figure 2.11

Dose-response lines from a variety of animal experiments. For each experiment, I list the slope of the line, −r/n = −1/s, from Eq. (2.4): (×) methylcholanthrene applied to mouse skin three times per week, skin tumors with slope of −1/2.1; (+) 4-dimethylaminoazobenzene fed to rats in daily diet (dosage multiplied by 1000), liver tumors with slope of −1/1.1; (filled circle) 3,4-benzopyrene applied to mouse skin three times per week, skin tumors with slope of −1/4.0; (open triangle) methylcholanthrene given as a single subcutaneous injection to mice, duration measured as time after exposure, sarcomas with slope of −1/4.0; (open circle) 1,2,5,6-dibenzanthracene given as a single subcutaneous injection to mice, sarcomas with slope of −1/4.7; (filled triangle) 3,4-benzopyrene, single subcutaneous injection to mice, sarcomas with slope of −1/4.7; (open square) diethylnitrosamine fed to rats in daily diet, liver tumors with slope of −1/2.3; (filled square) dimethylaminostilbene fed to rats in daily diet, ear duct tumors with slope of −1/3.0. Redrawn from Figure 9 of Druckrey (1967).

From: Chapter 2, Age of Cancer Incidence

Cover of Dynamics of Cancer
Dynamics of Cancer: Incidence, Inheritance, and Evolution.
Frank SA.
Princeton (NJ): Princeton University Press; 2007.
Copyright © 2007, Steven A Frank.

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