Figure 13.4. The proportion of cancers that arise from cells mutated during development.

Figure 13.4

The proportion of cancers that arise from cells mutated during development. These plots show calculations based on a specific four-stage model of colorectal cancer progression (Meza et al. 2005). The parameters of the progression model were estimated from incidence data. The values of u above each plot show the mutation rate per year in stem cells. Stem cells likely divide between 10 and 100 times per year, thus a mutation rate per year of at least 10−5 per locus seems reasonable. In each plot, the three curves sketch the heterogeneity between individuals in risk attributable to developmental mutations. The first quartile shows the proportion of cancers at each age for those individuals whose risk is in the lowest 25% of the population, in particular, those individuals who by chance have the fewest stem cells mutated during development. Similarly, the fourth quartile shows the risk for the highest 25% of the population with regard to developmental mutations. From Meza et al. (2005).

From: Chapter 13, Stem Cells: Population Genetics

Cover of Dynamics of Cancer
Dynamics of Cancer: Incidence, Inheritance, and Evolution.
Frank SA.
Princeton (NJ): Princeton University Press; 2007.
Copyright © 2007, Steven A Frank.

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