Table 1Drugs available for the treatment of trypanosomatid-borne diseases

DiseaseDrug (Date Introduced)Limitations
African Sleeping SicknessSuramin (1920)Toxicity, not effective in late-stage disease, injected
Pentamidine (1939)Toxicity, not effective in late-stage disease, injected, resistance
Melarsoprol (1949)Toxicity, injected, resistance
Eflornithine (1991)Cost, injected, only effective against T. gembiense.
Chagas’ DiseaseNifurtimox (1970)Toxicity, long-term compliance, only effective in acute stage
Benznidazole (1974)Toxicity, only effective in acute stage
LeishmaniasisPentamidine (1939)Toxicity, injected, resistance
Antimonials (1950)Toxicity, injected, resistance
Liposomal Amphotericin B (1990)Cost, injected
Miltefosine (2002)Contraindicated in pregnancy

(Adapted from ref. 1).

From: Identification of Selective Inhibitors of Phosphofructokinase as Lead Compounds Against Trypanosomiasis

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