Table 61Strength of evidence: comparative adverse events for oral selective antihistamine versus oral decongestant

OutcomeSeverityCitationFavorsa Oral S-AH RDFavorsa Neither RD = 0Favorsa Oral Decongestant RDUSPSTFActive?bPt Blind?Assessor Blind?Risk of BiasConsDirPrecSOE
SedationUnspecifiedBronsky,19951011.0GYYY
Grosclaude,19971033.0GYYY
Pleskow, 20051051.0PNYY
Schenkel, 2002106c0.1FNYY
Sussman,1999107c1.4GYYY
MedInconsDirImprecInsuf
HeadacheUnspecifiedBronsky,19951013.0GYYY
Grosclaude,19971032.8GYYY
Grubbe, 20091044.9PYYY
Pleskow, 20051050PNYY
Chervinsky, 2005102d2.0PIntYY
Schenkel, 2002106c1.7FNYY
Sussman,1999107c5.1GYYY
MedInconsDirImprecInsuf
InsomniaUnspecifiedBronsky,19951018.0*GIntYY
Grosclaude,199710311.1*GYYY
Grubbe, 200910411.0*PYYY
Pleskow, 20051056.0*PNYY
Chervinsky, 2005102d9.0PIntYY
Schenkel, 2002106c7.3FNYY
Sussman,1999107c11.0GYYY
MedConsDirPrecMod
AnxietyUnspecifiedBronsky,19951013.0GYYY
Grosclaude,19971032.2*GYYY
Pleskow, 20051052.0PNYY
Schenkel, 2002106c0.3FNYY
Sussman,1999107c1.4GYYY
MedConsDirImprecInsuf

Cons = consistent; Dir = direct; F = fair; G = good; Imprec = imprecision; Incon = inconsistent; Insuf = insufficient; Int = intermediate; Mod = moderate; N = no; P = poor; Prec = precise; Pt = patient; RD = risk difference; S-AH = selective antihistamine; SOE = strength of evidence; USPSTF = U.S. Preventive Services Task Force; Y = yes.

a

Values are not statistically significant unless otherwise indicated. “Favors” indicates avoidance of harm.

b

The process of harms ascertainment was characterized as active, passive, or intermediate as defined in the Methods section.

c

Denominator was reports, not patients. Confidence limits not calculated to assess strength of evidence.

d

Unclear if denominator was reports or patients. Confidence limits not calculated to assess strength of evidence.

*

p<0.05, calculated by CER authors.

From: Results

Cover of Treatments for Seasonal Allergic Rhinitis
Treatments for Seasonal Allergic Rhinitis [Internet].
Comparative Effectiveness Reviews, No. 120.
Glacy J, Putnam K, Godfrey S, et al.

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