Table 48Treatment effects: nasal symptoms–combination intranasal corticosteroid plus nasal antihistamine versus intranasal corticosteroid

OutcomeVarianceaSS Favors Combo MDNSS Favors/NR Combo MDFavors Neither MD=0NSS Favors/NR INCS MDSS Favors INCS MD
2 Weeks, Average Change From Baseline
Congestion
 Carr, 2012 (Trial 1)115 (scale 0-6)SD/CI0.2 (-0.06, 0.38)b
 Carr, 2012 (Trial 2)115 (scale 0-6)SD/CI0.3 (0.04, 0.52)b
 Carr, 2012 (Trial 3)115 (scale 0-6)SD/CI0.1 (-0.03, 0.28,)b
 Hampel, 2010117 (scale 0-6)0.38
 Ratner, 2008121 (scale 0-6)SD0.6
Rhinorrhea
 Carr, 2012 (Trial 1)115 (scale 0-6)SD/CI0.25 (0.01, 0.50)
 Carr, 2012 (Trial 2)115 (scale 0-6)SD/CI0.2 (-0.12, 0.41)b
 Carr, 2012 (Trial 3)115 (scale 0-6)SD/CI0.1 (-0.05, 0.29)b
 Hampel, 2010117 (scale 0-6)0.27 (NR)
 Ratner, 2008121 (scale 0-6)SD0.4 (NSS)
Sneezing
 Carr, 2012 (Trial 1)115 (scale 0-6)SD/CI0.19 (-0.06, 0.44)b
 Carr, 2012 (Trial 2)115 (scale 0-6)SD/CI0.3 (0.01, 0.56)b
 Carr, 2012 (Trial 3)115 (scale 0-6)SD/CI0.2 (0.04, 0.40)b
 Hampel, 2010117 (scale 0-6)0.49
 Ratner, 2008121 (scale 0-6)SD0.6
Itching
 Carr, 2012 (Trial 1)115 (scale 0-6)SD/CI0.2 (-0.01, 0.47)b
 Carr, 2012 (Trial 2)115 (scale 0-6)SD/CI0.2 (-0.02, 0.50)b
 Carr, 2012 (Trial 3)115 (scale 0-6)SD/CI0.1 (-0.04, 0.27)b
 Hampel, 2010117 (scale 0-6)0.31
 Ratner, 2008121 (scale 0-6)SD0.6
TNSS
 Carr, 2012 (Trial 1)115 (scale 0-24)SD/CI0.9 (0.07, 1.74)b
 Carr, 2012 (Trial 2)115 (scale 0-24)SD/CI1.0 (0.05, 1.91)b
 Carr, 2012 (Trial 3)115 (scale 0-24)SD/CI0.6 (0.07, 1.22)b
 Hampel, 2010117 (scale 0-24)IQR1.47
 Ratner, 2008121 (scale 0-24)SD2.2

INCS = Intranasal corticosteroid; MD = mean difference (calculated by authors with available data except where noted); NR = p-value not reported; NSS = not statistically significant; SS = statistically significant; TNSS = total nasal symptom score.

a

Variance/confidence interval reported: CI=confidence interval; IQR = interquartile range; SD=standard deviation; SE=standard error.

b

Differences between least squares means adjusted for center and baseline severity as reported by trial authors.

From: Results

Cover of Treatments for Seasonal Allergic Rhinitis
Treatments for Seasonal Allergic Rhinitis [Internet].
Comparative Effectiveness Reviews, No. 120.
Glacy J, Putnam K, Godfrey S, et al.

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