Table 43Strength of evidence: combination oral selective antihistamine plus intranasal corticosteroid versus intranasal corticosteroid

OutcomeRCTs (Patients)Risk of BiasConsistencyDirectnessPrecisionOverall GRADE
2-week congestion, rhinorrhea262, 90 (407)HighInconsistentDirectImpreciseInsufficient
2-week sneezing, nasal itch262, 90 (407)HighConsistentDirectImpreciseInsufficient
2-week TNSS362, 90, 98 (707)HighConsistentDirectImpreciseInsufficient
2-week eye symptoms (itching, tearing, redness)190 (345)HighUnknown (single study)DirectImpreciseInsufficient
2-week QoL262, 98 (362)MediumInconsistentDirectImpreciseInsufficient
6-week congestion, rhinorrhea, sneezing, nasal itch1132 (40)HighUnknown (single study)DirectImpreciseInsufficient
6 and 8-week TNSS2131, 132 (494)LowInconsistentDirectImpreciseInsufficient
8-week TOSS1131 (454)LowUnknown (single study)DirectImpreciseInsufficient

GRADE = Grading of Recommendations Assessment, Development and Evaluation; QoL = quality of life; RCTs (Patients) = number of randomized controlled trials (number of patients randomized to treatment groups of interest); TOSS = total ocular symptom score; TNSS = total nasal symptom score.

From: Results

Cover of Treatments for Seasonal Allergic Rhinitis
Treatments for Seasonal Allergic Rhinitis [Internet].
Comparative Effectiveness Reviews, No. 120.
Glacy J, Putnam K, Godfrey S, et al.

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