Appendix Table C11Trial description: oral selective antihistamine versus intranasal corticosteroid

Author, YearLocation/Site(s)Enrollment/Treatment DurationFunding/Author Industry DisclosuresNInclusion CriteriaExclusion CriteriaaRescue Medication UseObjective DiagnosisRun-in PeriodPollen Counts MeasuredPatient BlindingAssessor Blinding
Andrews, 2009 (Trial 1)N. America
Multi-center
2006
2 weeks
Industry
Yes
623Minimum SAR severity and durationSAR meds/+
Chronic asthma
Pregnancy
Infection
Deformities
No
Andrews, 2009 (Trial 2)N. America
Multi-center
2007
2 weeks
Industry
Yes
451Minimum SAR severity and durationSAR meds/+
Other meds
Chronic asthma
Pregnancy
Infection
Deformities
No
Anolik, 2008N. America
Multi-center
March 1995
15 days
NR
Yes
526Minimum SAR severity and durationChronic asthma
Immunotherapy
Infection
Deformities
No
Bernstein, 2004N. America
Multi-center
4 weeksIndustry
Yes
316Minimum SAR severity and durationSAR meds/NRNo
Condemi, 2000N. America
Multi-center
4 weeksIndustry
Yes
351Minimum SAR severity and durationSAR meds/+
Other meds
Pregnancy
Infection
Deformities
No
Gawchik, 1997N. America
Multi-center
4 weeksIndustry
Yes
305Minimum SAR severity and durationSAR meds/+
Other meds
Immunotherapy
Pregnancy
Infection
Gehanno, 1997Europe
Multi-center
March 1991
4 weeks
Industry
Yes
114Minimum SAR severitySAR meds/+
Pregnancy
Yes
Jordana, 1996N. America
Multi-center
4 weeksIndustry
Yes
242SAR meds/-
Pregnancy
Infection
Deformities
Yes
Kaszuba, 2001N. America
Single center
August 1999
4 weeks
Industry, NIH
No
88Minimum SAR durationSAR meds/+
Pregnancy
Deformities
No
Lu, 2009 (Trial 1)N. America
Multi-center
April 1998
2 weeks
Industry
Yes
289Minimum SAR severity and durationNo
Ratner, 1998N. America
Multi-center
2 weeksIndustry
Yes
450Minimum SAR severity and durationSAR meds/+
Pregnancy
Infection
Deformities
No
Schoenwetter, 1995N. America
Multi-center
4 weeksIndustry
Yes
298Minimum SAR severity and durationSAR meds/+
Other meds
Pregnancy
Infection
Deformities
No
Vervloet, 1997Europe
Multi-center
3 weeksIndustry
Yes
238Minimum SAR severitySAR meds/+
Immunotherapy
Pregnancy
Deformities
Yes

N = Patients randomized to comparator groups of interest; NIH = National Institutes of Health; NR = not reported; SAR = seasonal allergic rhinitis.

a

+, -, or NR indicates whether FDA-recommended washout periods were required (+), were not required (-), or were not reported (NR) for restricted SAR medications prior to trial entry.

From: Appendix C, Evidence Tables

Cover of Treatments for Seasonal Allergic Rhinitis
Treatments for Seasonal Allergic Rhinitis [Internet].
Comparative Effectiveness Reviews, No. 120.
Glacy J, Putnam K, Godfrey S, et al.

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