Table 3Activity of analogs with modifications on sulfonamide and piperazine moieties

#CIDSIDNCGCStructureIC50”(μM) BlueIC50”(μM) Red
1ML201
20969430
89650104NCGC00187771-02
Image ml201fu35.jpg
0.520.37
324482530089650116NCGC00188694-01
Image ml201fu36.jpg
inactiveinactive
334482530189650117NCGC00188695-01
Image ml201fu37.jpg
inactiveinactive
344482529189650103NCGC00187770-01
Image ml201fu38.jpg
inactiveinactive

From: 5-(4-(4-Acetylphenyl)piperazin-1-ylsulfonyl)indolin-2-one Analogs as Inhibitors of Acid alpha-Glucosidase for Potential Chaperone Treatment of Pompe Disease or Intervention for Diabetes Mellitus Type 2

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.