Figure 7. A) [1-14C]glucose flux through PPP to generate 14CO2 in response to diamide was measured in DMSO and ML285 treated cells.

Figure 7

A) [1-14C]glucose flux through PPP to generate 14CO2 in response to diamide was measured in DMSO and ML285 treated cells. B) Changes in G-6-P levels were measured in response to diamide treatment and were measured in DMSO and ML285 treated cells. C) GSH levels were measured in cells expressing WT PKM2, C358 PKM2 as well as WT PKM2 that was treated with either DMSO or ML285. D) GSH levels measured in A549 cells expressing exclusively either Flag-PKM1 or Flag-PKM2 and treated with ML285. ROS levels were measured with increasing concentrations of H2O2 in either DMSO or ML285 treated cells.

From: ML285 affects reactive oxygen species’ inhibition of pyruvate kinase M2

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