Figure 1 is an analytic framework that depicts the events that individuals experience while undergoing evaluation of coronary artery disease and treatment with revascularization, including medical therapy, coronary artery bypass grafting, and percutaneous coronary intervention with stenting. The framework includes the following: Patient Population of Interest, Treatment, Imaging and diagnostic techniques, Therapeutic decisionmaking, Surrogate Outcome Measures, Stent-related Outcomes, Clinical Outcomes and Adverse Effects of Treatment. Our patient population of interest is patients with coronary artery disease. The treatment is coronary stenting. Imaging and diagnostic techniques are intravascular adjunctive techniques (referred here as intravascular diagnostic techniques) and angiography. The intermediate outcome measures are utilized to determine if the treatment is effective and include minimal lumen diameter, reference diameter, and percent diameter stenosis. Clinical outcomes include death (any cause or cardiac), myocardial infarction, repeat revascularization, major adverse cardiac event, quality of life/satisfaction with treatment, and survival. Adverse effects include procedural complications, and stent-related outcomes include stent thrombosis and binary restenosis.

Figure 1Analytic framework

Abbreviations: CAD = coronary artery disease; KQ = Key Question; MACE = major adverse cardiac events; MI = myocardial infarction; QoL = quality of life

From: Background

Cover of Intravascular Diagnostic Procedures and Imaging Techniques Versus Angiography Alone in Coronary Stenting: Future Research Needs
Intravascular Diagnostic Procedures and Imaging Techniques Versus Angiography Alone in Coronary Stenting: Future Research Needs: Identification of Future Research Needs From Comparative Effectiveness Review No. 104 [Internet].
Future Research Needs Papers, No. 25.
Ip S, Raman G, Concannon TW, et al.

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