Appendix EExcluded Studies

Publication Details

All studies listed below were reviewed in their full-text version and excluded for the reason shown in bold. Reasons for exclusion signify only the usefulness of the articles for this study and are not intended as criticisms of the articles.

Non-English language

  1. Brosa M, Garcia-Cases C, Clerch L, et al. Cost-effectiveness analysis of cilostazol vs naftidrofuryl and pentoxifylline for the treatment of intermittent claudication in Spain. Angiologia. 2011;63(3):103–7.
  2. Bulvas M, Chochola M, Herdova J, et al. Influence of heparan sulphate on the effect of percutaneous transluminal angioplasty in vessels supplying the lower extremities. Cas Lek Cesk. 1996;135(14):445–9. [PubMed: 8925544]
  3. Chikiar DS, Grandjean M, Abelleyra J. Femoropopliteal bypass grafting for arterial occlusive disease. Patency and complications. Randomized retrospective study. Prensa Med Argent. 2003;90(4):338–44.
  4. Gloor B, Wehrli E, Rotzer A, et al. Polyurethane small artery substitutes for femoropopliteal above knee bypass. Clinical and angiomorphological follow up of 20 patients in a prospective, randomized trial. Swiss Surg. 1996;(Suppl 1):13–8. [PubMed: 8653568]
  5. Grenacher L, Saam T, Geier A, et al. [PTA versus Palmaz stent placement in femoropopliteal artery stenoses: results of a multicenter prospective randomized study (REFSA)]. RoFo. 2004;176(9):1302–10. [PubMed: 15346266]
  6. Leo W, Westrych R, Bissinger A, et al. [Effect of the acetylosalicyd acid (ASA) and ticlopidine therapy on clinical condition and parameters of blood platelets in patients with peripheral arterial occlusive disease (PAOD)]. Pol Merkuriusz Lek. 2007;23(137):335–9. [PubMed: 18361314]
  7. Marinel-Lo-Roura J, Alos-Vilacrosa J, Lopez-Palencia JA, et al. Endovascular surgery of the infrapopliteal segment. Angiologia. 2003;55(Suppl 1):S175–81.
  8. Martin-Conejero A, Serrano-Hernando FJ, Rodriguez-Gonzalez R, et al. Treatment of occlusive pathologies of the superficial femoral artery with a Viabahn(registered trademark) device. Angiologia. 2008;60(2):117–25.
  9. Matas-Docampo M, Royo-Serrando J, Dominguez-Gonzalez JM, et al. Endovascular surgery of the distal segment: The opposite position. Angiologia. 2003;55(Suppl 1):S182–9.
  10. Mosimann UP, Stirnemann P. Chronic critical limb ischemia: The revascularization of the isolated popliteal segment compared to the femoro-distal bypass. Vasa. 1995;24(1):49–55. [PubMed: 7725779]
  11. Nasser F, Silva SGDJ, Biagioni RB, et al. Endovascular infrainguinal revascularization: Predictive factors for patency. J Vasc Bras. 2009;8(1):48–55.
  12. Nicolai SPA, Prins MH, Teijink JaW. Supervised exercise therapy is more effective than walking advice in patients with intermittent claudication; a randomized multicenter study. Ned Tijdschr Geneeskd. 2011;155(2):55–62.
  13. Ortigosa Mateo AB, Gutierrez Julian JM, Rivas Dominguez M, et al. Clinical results of femoropopliteal endovascular treatment in patients with critical limb ischaemia. Angiologia. 2010;62(3):103–9.
  14. Panella-Agusti F, Berga-Fauria C, Hernandez-Osma E, et al. Iliofemoral or femorofemoral by-pass. Which is the best option? A long-term follow-up study. Angiologia. 2003;55(6):526–33.
  15. Plaza-Martinez A, Riera-Vazquez R, Diaz-Lopez M, et al. Value of endovascular treatment in the iliac sector. Angiologia. 2002;54(4):282–90.
  16. Ramirez Saavedra OA. Sequential distal bypass: A resolved surgery in diabetic foot with TASC D gangrene and lesions. Rev Mex Angiol. 2010;38(2):46–50.
  17. Rognoni A, Zelaschi F, Felicetti G, et al. Rehabilitation of the peripheral arterial obstructive disease: Efficacy of aerobic training. Eur Medicophys. 1995;31(4):207–13.
  18. Schlenger R. Cilostazol therapy improves the ability to walk in patients with peripheral occlusive artery disease. Dtsch Apoth Ztg. 2007;147(10):34–6.
  19. Stierli P, Eugster T, Hess P, et al. Occlusion of the superficial femoral artery. Choice of material for a bypass to the above-knee popliteal artery. Gefasschirurgie. 2001;6(Suppl 1):S43–6.
  20. Tan JY, Shi WH, He J, et al. [A clinical trial of using antiplatelet therapy to prevent restenosis following peripheral artery angioplasty and stenting]. Nat Med J China. 2008;88(12):812–5. [PubMed: 18756983]
  21. Tetteroo E, Van Der Graaf Y, Van Engelen AD, et al. No difference in effect on intermittent claudication between primary stent placement and primary percutaneous transluminal angio plasty followed by selective stent placement: A prospective randomized trial. Ned Tijdschr Geneeskd. 2000;144:167–71.
  22. Trejo JMR, Sanchez IE, Ramirez NR, et al. Surgery for the rescue of critical limb ischemia. Rev Mex Angiol. 2008;36(3):88–97.
  23. Utrilla-Fernandez F, Acin-Garcia F, March-Garcia JR, et al. Angioplasty versus angioplasty plus stent-graft in the infrainguinal segment. Results of 100 consecutive endovascular procedures. Angiologia. 2004;56(4):367–79.
  24. Van Der Zaag ES, Prins MH, Jacobs MJ. [Treatment of intermittent claudication; prospective randomized study in the BAESIC-Trial (bypass, angioplasty or endarterectomy patients with severe intermittent claudication)]. Ned Tijdschr Geneeskd. 1996;140(14):787–8. [PubMed: 8668267]
  25. Zhu BP, Fan L, Li XY. [Long-term effect and reliability of warfarin and aspirin for primary prevention of cardio-cerebral vessels events in patients with peripheral arteriosclerotic occlusive disease: a randomized, single-blind, controlled clinical trial with two-year follow-up]. Chin J Clin Rehab. 2005;9(15):10–1.
  26. Zimmermann A, Berger H, Eckstein HH. The ABC (angioplasty or bypass surgery in intermittent claudication) trial: Background and study design. Gefasschirurgie. 2010;15(1):5–10.

Not a full publication (abstract only), not original data, not peer-reviewed literature published 1995 to present, not a clinical study (e.g., editorial, non-systematic review, letter to the editor, case series), animal study

  1. Ahanchi SS, Chen B, Steerman S, et al. The use of reentry devices improves the technical success, safety, and patency of recanalization of chronic total occlusions of the iliac arteries. J Vasc Surg. 2012;55(6 Suppl 1):88S–89S.
  2. Anonymous. Meta-analysis of antiplatelet trials. Pharm J. 2002;268(7180):7.
  3. Anonymous. Stenting for peripheral artery disease of the lower extremities: An evidence-based analysis. Ont Health Technol Assess Ser. 2010;10(18):1–88. [PMC free article: PMC3377569] [PubMed: 23074395]
  4. Atsushi T, Soga Y, Iida O, et al. Predictors of early mortality in patients with critical limb ischemia caused by isolated below-the-knee artery disease. J Am Coll Cardiol. 2012;59(13Suppl 1):E2109.
  5. Beebe HG, Dawson DL, Cutler BS, et al. Cilostazol, a new treatment for intermittent claudication: results of a randomized, multicenter trial. Circulation. 1997;96(8):66.
  6. Belch J, Maccuish A, Campbell I. No benefit of daily low-dose aspirin in diabetic patients with peripheral arterial disease. J Clin Outcomes Manage. 2008;15(12):575–6.
  7. Belkin M, Donaldson MC, Whittemore AD. Composite autogenous vein grafts. Semin Vasc Surg. 1995;8(3):202–8. [PubMed: 8564033]
  8. Bell J, Papp L, Bradbury AW. Bypass or angioplasty for sever ischaemia of the leg: the BASIL trial. Vascular and endovascular opportunities. 2000:485–94.
  9. Bosch JL, Tetteroo E, Mali WP, et al. Iliac arterial occlusive disease: cost-effectiveness analysis of stent placement versus percutaneous transluminal angioplasty. Dutch Iliac Stent Trial Study Group. Radiology. 1998;208(3):641–8. [PubMed: 9722840]
  10. Bradbury AW, Adam DJ, Bell J, et al. Erratum: Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) Trial: a description of the severity and extent of disease using the Bollinger angiogram scoring method and the TransAtlantic Inter-Society Consensus II classification. (J Vasc Surg. 2010;51( Suppl.5):32S-42S) J Vasc Surg. 2010;(6):1751. [PubMed: 20435260]
  11. Bradbury AW, Adam DJ, Bell J, et al. Erratum: Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) Trial: a survival prediction model to facilitate clinical decision making. (J Vasc Surg. 2010;51(Suppl.5):52S-68S) J Vasc Surg. 2010;(6):1751. [PubMed: 20435262]
  12. Bradbury AW, Adam DJ, Bell J, et al. Erratum: Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) Trial: an intention-to-treat analysis of amputation-free and overall survival in patients randomized to a bypass surgery-first or a balloon angioplasty-first revascularization strategy. (J Vasc Surg. 2010;51(Suppl.5):5S-17S) J Vasc Surg. 2010;(6):1751. [PubMed: 20435258]
  13. Bradbury AW, Adam DJ, Bell J, et al. Erratum: Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) Trial: analysis of amputation free and overall survival by treatment received. (J Vasc Surg. 2010;51(Suppl.5):18S-31S) J Vasc Surg. 2010;(6):1751. [PubMed: 20435259]
  14. Breek JC, De Vries J, Hamming JF. The Oslo Balloon Angioplasty versus Conservative Treatment Study (OBACT) - The 2-years results of a single centre, prospective, randomised study in patients with intermittent claudication. Eur J Vasc Endovasc Surg. 2007;34(3):378. [PubMed: 17582794]
  15. Caro JJ, Migliaccio-Walle K. Generalizing the results of clinical trials to actual practice: the example of clopidogrel therapy for the prevention of vascular events. CAPRA (CAPRIE Actual Practice Rates Analysis) Study Group. Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events. Am J Med. 1999;107(6):568–72. [PubMed: 10625025]
  16. Cassar K, Bachoo P, Ford I, et al. Variability in responsiveness to clopidogrel in patients with intermittent claudication. The Vascular Society of Great Britain & Ireland Yearbook. 2005. 2005;Abstract no: 66.
  17. Cassar K, Ford I, Greaves M, et al. The CAVA study: a double-blind randomized controlled trial of clopidogrel and aspirin vs. aspirin alone in patients with intermittent claudication undergoing peripheral percutaneous transluminal angioplasty. J Thromb Haemost. 2003;(Suppl 1) Abstract no: P2009.
  18. Cejna M, Durakovic N, Mathies R, et al. Long-term follow-up and total cost analysis of in-hospital invasive interdisciplinary treatment of critical limb ischemia: Comparison of surgical and endovascular therapy. CardioVascular and Interventional Radiology. 2011;34(Suppl 3):528.
  19. Clement Darling R, Mehta M, Roddy SP, et al. Distal bypass in the endovascular-first era: Is there still a need for open surgery? J Vasc Surg. 2011;54(3):922–3.
  20. Cull DL, Langan EM, Gray BH, et al. Open versus endovascular intervention for critical limb ischemia: a population-based study. J Am Coll Surg. 2010;210(5):555–61. 561–3. [PubMed: 20421003]
  21. Dardik H. Regarding “a comparative evaluation of polytetrafluoroethylene, umbilical vein, and saphenous vein bypass grafts for femoral-popliteal above-knee revascularization: a prospective randomized Department of Veterans Affairs cooperative study” J Vasc Surg. 2001;33(3):658–9. [PubMed: 11241144]
  22. Dawson DL, Beebe HG, Herd JA, et al. Cilostazol or pentoxifylline for claudication. Circulation. 1998;(Suppl 1):12.
  23. Drozdz W, Lejman W. Response to exercise training in patients with intermittent claudication. Pol Prz Chir. 2006;78(1):85–105.
  24. Farkouh ME. 2008-- aspirin and/or antioxidants did not prevent CV events in diabetes and peripheral arterial disease. ACP Journal Club. 2009;150:JC1–8. [PubMed: 19172713]
  25. Flis V, Pavlovic M, Miksic K. The value of adjunctive vein patches to improve the outcome of femorodistal polytetrafluoroethylene bypass grafts. Wien Klin Wochenschr. 2001;113(Suppl.3):5–10. [PubMed: 15503612]
  26. Friedberg MW. Supervised exercise is equivalent to endovascular revascularization for the treatment of intermittent claudication. J Clin Outcomes Manage. 2009;16(8):349–50.
  27. Gaines P. Results of bypass vs. interventional radiology for occlusive disease. Cardiovasc Intervent Radiol. 2011;34(Suppl.3):336–8.
  28. Gardner AW, Montgomery PS, Parker DE. Optimal exercise program length for patients with claudication: A randomized controlled trial. J Cardiopulm Rehabil Prev. 2011;31(4):E4–5.
  29. Gardner AW. Supervised exercise therapy provided by local physiotherapists improves walking distance in patients with claudication. Evid-Based Med. 2011;16(2):43–4. [PubMed: 21427053]
  30. Greenhalgh J, Bagust A, Boland A, et al. Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular events (review of Technology Appraisal No. 90): a systematic review and economic analysis. Health Technol Assess. 2011;15(31):1–178. [PMC free article: PMC4781064] [PubMed: 21888837]
  31. Grenon SM, Conte MS. Aspirin prophylaxis (100 mg daily) does not improve cardiovascular outcomes compared to placebo in asymptomatic individuals with incidental low-ankle brachial index. Evid-Based Med. 2010;15(4):106–8. [PubMed: 20530607]
  32. Guest JF, Davie AM, Clegg JP. Cost effectiveness of cilostazol compared with naftidrofuryl and pentoxifylline in the treatment of intermittent claudication in the UK. Curr Med Res Opin. 2005;21(6):817–26. [PubMed: 15969881]
  33. Hamburg NM, Balady GJ. Exercise rehabilitation in peripheral artery disease: functional impact and mechanisms of benefits. Circulation. 2011;123(1):87–97. [PMC free article: PMC3061490] [PubMed: 21200015]
  34. Harker LA, Boissel JP, Pilgrim AJ, et al. Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE. CAPRIE Steering Committee and Investigators. Clopidogrel versus aspirin in patients at risk of ischaemic events. Drug Saf. 1999;21(4):325–35. [PubMed: 10514023]
  35. Hepp W, Von Bary S, Corovic D, et al. Intravenous prostaglandin E1 versus pentoxifylline: a randomized controlled study in patients with intermittent claudication. Int Angiol. 1995;(Suppl 1):280.
  36. Hiatt WR, Cooper LT, Morgan RE, et al. Clinical effects of the phosphodiesterase inhibitor K-134 in peripheral artery disease and claudication. Circulation. 2011;124(21):A9800.
  37. Hong JB, Jeon YS, Cho SG, et al. Endovascular treatment as a reasonable option for extensive total occlusion of iliac artery. Am J Cardiol. 2012;109(7):138S–139S.
  38. Huber TS. Commentary. Anand, Yusuf, Xie, et al. The Warfarin Antiplatelet Vascular Evaluation Trial Investigators. Oral anticoagulation and antiplatelet therapy and peripheral arterial disease. N Engl J Med. 2007;357:217-227. Perspect Vasc Surg Endovasc Ther. 2008;20(4):383–4. [PubMed: 19095638]
  39. Hunink MG, Wong JB, Donaldson MC, et al. Revascularization for femoropopliteal disease. A decision and cost-effectiveness analysis. JAMA. 1995;274(2):165–71. [PubMed: 7596006]
  40. Jacomella V, Shenoy A, Mosimann K, et al. Impact of lower limb revascularization on aortic augmentation index and subendocardial viability ratio in patients with peripheral arterial disease. Atheroscler Suppl. 2011;12(1):70.
  41. Kalani M, Apelqvist J, Blomback M, et al. Dalteparin improved chronic foot ulcers and reduced the number of amputations in diabetic peripheral arterial occlusive disease. Evid-Based Med. 2004;9(3):73.
  42. Karnon J, Brennan A, Pandor A, et al. Modelling the long term cost effectiveness of clopidogrel for the secondary prevention of occlusive vascular events in the UK. Curr Med Res Opin. 2005;21(1):101–12. [PubMed: 15881481]
  43. Killewich LA. Improving functional status and quality of life in elderly patients with peripheral arterial disease. J Am Coll Surg. 2006;202(2):345–55. [PubMed: 16427563]
  44. Kruidenier LM, Nicola SP. Additional supervised exercise therapy after a percutaneous vascular intervention for peripheral arterial disease: A randomized clinical trial. J Vasc Surg. 2011;54(6):1846. [PubMed: 21571547]
  45. Lee HL, Mehta T, Ray B, et al. A trial of the clinical and cost-effectiveness of a supervised exercise programme for claudication. Br J Surg. 2005;92(Suppl 1):11.
  46. Masser PA, Taylor LM Jr, Moneta GL, et al. Technique of reversed vein bypass for lower extremity ischemia. Ann Vasc Surg. 1996;10(2):190–200. [PubMed: 8733873]
  47. Mazari F, Khan J, Abdul Rahman MNA, et al. Cost utility analysis of a randomised control trial of percutaneous transluminal angioplasty (PTA), supervised exercise programme (SEP) and combined treatment (PTA+SEP) for patients with intermittent claudication (IC) due to femoropopliteal disease. The Vascular Society of Great Britain & Ireland Yearbook. 2009;2009:44.
  48. Mehta M, Ramay F, Roddy SP, et al. Cost per day of patency: Long-term implications of patency and reinterventions after endovascular vs surgical lower extremity revascularizations. J Vasc Surg. 2011;54(4):1227–8.
  49. Melton C. Supervised exercise program helps patients with peripheral artery disease walk longer. Clin Geriatr. 2011;19(12):17.
  50. Mewissen MW. IX.4 direct stenting in long femoropopliteal lesions. Vascular. 2005;13(Suppl 1):S47–9.
  51. Mohler ER 3rd, Beebe HG, Salles-Cuhna S, et al. Effects of cilostazol on resting ankle pressures and exercise-induced ischemia in patients with intermittent claudication. Vasc Med. 2001;6(3):151–6. [PubMed: 11789969]
  52. Murphy TP. Supervised exercise vs. primary stenting for claudication due to aorto-iliac peripheral artery disease: 6-month outcomes from the CLEVER Study. Eur Heart J. 2012;33(1):144–5.
  53. Nair V, Chaisson G, Abben R. Strategies in infrapopliteal intervention: improving outcomes in challenging patients. J Interv Cardiol. 2009;22(1):27–36. [PubMed: 19281520]
  54. Nordanstig J, Gelin J, Hensater M, et al. Walking performance and health-related quality of life after surgical or endovascular invasive versus non-invasive treatment for intermittent claudication - A prospective randomised trial. J Vasc Surg. 2011;54(2):584. [PubMed: 21397530]
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Does not include a study population of interest

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No outcomes of interest ≥30 days

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