Table 15Summary of ablative therapy study and patient characteristics: case series studies

Study
N
Rating
Study DesignIntervention PeriodInterventionAge, Mean or Median (Range)ECOG ScoreCP
A%; B%; C%
BCLC
A%; B%
Previous LDT %
Chen et al. 201154
40
Fair
Retrospective case series01/2006 - 06/2009US-guided percutaneous cryotherapyMean: 59.3 (NR)NRA: 30;
B: 60;
C: 10
NRNR
Chen et al. 201154
26
Fair
Retrospective case series01/2006 - 06/2009US-guided percutaneous cryotherapyMean: 57.4 (NR)NRA: 23.1;
B: 69.2;
C: 7.7
NRNR
Itoh et al. 201155
60
Good
Prospective case series05/2003 - 12/2010Surgical microwave therapy administered for 60 s at a power setting of 65 W per pulse using a microwave electrode 1.6mm in diameter and 25cm in lengthMean: 67.7 (47–83)≤1: 100A: 68.3;
B: 31.6;
C: 0
NRNR
Minami et al. 200756
30
Poor
Prospective case series05/2000 - 09/2003Open RFA with cooled-tip needle guided by intraoperative sonographyMean: 63 (44–76)NRNRNRNR
Shen et al. 200557
16
Poor
Prospective cohort*09/2001 - 06/2004Percutaneous RFA with retractable curved electrodes (90W peak power) under US guidanceMedian: 56.1 (36–75)NRA: 37.5;
B: 62.5;
C: 0
NRNR
Singh et al. 2011 60
1
Poor
Case reportRFA under US guidance using cool-tip RFA probe46NRANRNR
Tanaka et al. 200958
20
Poor
Case series (uncertain if prospective or retrospective)07/2000 - 12/2002Open RFA via laparotomy (17) or thoracotomy (3)Median: 66 (NR)NRA: 50.0;
B: 45.0;
C: 5.0
NRNR
Zhou et al. 200959
42
Fair
Retrospective case series12/2003 - 12/2006Surgical cryoablation with argon (drop to -140°C for 15–20 min) and helium (raise to 20°C-40°C for 3–5 min) for 2–3 freezing-thawing cyclesMedian: 55.8 (NR)NRA: 66.7;
B: 33.3;
C: 0
A: 0;
B: 100
NR
*

Only a single arm of the two comparative arms was included in this evidence review.

Abbreviations: BCLC = Barcelona Clinic Liver Center hepatocellular carcinoma stage; CP = Child-Pugh liver cirrhosis class; ECOG = Eastern Cooperative Oncology Group; LDT = liver directed therapy; N = number of patients; NR = not reported; RFA = radiofrequency ablation; US = ultrasound.

From: Results

Cover of Local Therapies for Unresectable Primary Hepatocellular Carcinoma
Local Therapies for Unresectable Primary Hepatocellular Carcinoma [Internet].
Comparative Effectiveness Reviews, No. 114.
Belinson S, Yang Y, Chopra R, et al.

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