CID/ML#Target NameEC50 [SID, AID]Anti-target(s)IC50 [SID, AID]Fold SelectiveSecondary Assay(s): IC50 (nM) [SID, AID]
CID 57390068
SID 136920229 synthesized (small scale)

SID 144241486 synthesized (larger scale)
ML345
IDEIC50 = 188 nM

[SID 136920229, AID 624065]
HEK cytotoxicityEC50 >10 μM (inactive)

[SID136920229, AID 588709]
>50IC50 >100 μM, cysteine null mutant IDE enzyme [SID 136920229, AID 624338]

Activity-based protein profiling analysis: minimal effects vs. the cysteine-reactive proteome @ 2 μM [SID 144241486, AID pending]

From: ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE)

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