Table 7Nutrition therapy: Vitamin supplementation with vitamin C or zinc

Author Year
Quality
Study Type
Number Enrolled/Completed
Setting
Pressure Ulcer StageaAge
Sex
Population
Duration/FollowupNutrition Interventions ComparedOutcome Measures and Treatment EffectBenefit:
Wound Improvement
Houston
200168
Observational
Fair

N=70/68
Nursing facility
II–IVNR (NR)
Female: NR
Elderly
30 daysA: 440 mg/day zinc sulfate

B: Similar care without zinc sulfate supplementation
Complete wound healing: NR

Wound healing: greater improvement in volume in Stage III and IV, not Stage II (p<0.05)
No difference in surface area or complete closure

Harms (A vs. B):
Infection requiring antibiotic: Odds ratio=7.8 (p=0.0009)
Nausea/vomiting: Odds ratio=12.5 (p=0.02)
~
Ter Riet54b
Trial
Good

N=88/67
Nursing facility/hospital
II, IIINR (NR)
Female: NR
Residents of nursing facilities
12 weeksA: Ascorbic acid supplementation, 500 mg twice daily

B: Ascorbic acid, 10 mg twice daily
Complete wound healing:
A: 40% (n=17)
B: 55% (n=25)

Mean wound surface area reduction per week:
A: 13.9%
B: 22.9% (NS)

No difference between groups in wound survival curves (projected time to healing)

Harms: None
~

NPUAP = National Pressure Ulcer Advisory Panel; NR = not reported; NS = not significant

a

Pressure ulcer stage indicates NPUAP staging unless otherwise stated. Non-NPUAP staging was converted to the equivalent NPUAP stage where possible.

b

A 1974 publication, Taylor also evaluated Vitamin C but did not meet the inclusion criteria because of our 1985 cutoff.

++Complete wound healing.

+Some improvement.

~No difference.

From: Results

Cover of Pressure Ulcer Treatment Strategies: Comparative Effectiveness
Pressure Ulcer Treatment Strategies: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 90.
Saha S, Smith MEB, Totten A, et al.

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