Figure 2. Dose Response Curves for the Probe (ML312).

Figure 2Dose Response Curves for the Probe (ML312)

ML312 was used over a range of concentrations up to 35 μM in the primary DiI-HDL uptake assay, IC50=0.06 μM (AID 623880) (A), Alexa-488 HDL binding assay, AC50 = 0.44 μM (AID 624024) (B), 24-h CellTiter-Glo cytotoxicity, IC50 > 35 μM (AID 623895) (C), and the DiI-HDL ldlA7 counterscreen, IC50 >35 μM (AID 624007) (D). Dose curves were generated with Genedata Condeseo and shows normalized percent activity for the individual doses. ○=replicate 1, △=replicate 2

From: A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake - Probe 3

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