Table 7Bioactivity of Various Intermediates

Entry No.CID
SID
Broad ID
P/S*CompoundPBS Solubility (μM)Growth Inhibition Activity, IC50 (μM)
C. albicans (n = 3)3T3 Fibroblasts (n = 1)
CaCi-2CaCi-17
1 (hit)3889161
131404760
BRD-K97464451-001-02-7
S
Image ml316fu41.jpg
<1.00.38.5Inactive
256604883
134356663
BRD-K15707586-001-01-8
S
Image ml316fu48.jpg
14inactiveinactiveInactive
356604884
134356642
BRD-K51157407-001-01-8
S
Image ml316fu49.jpg
21inactiveinactiveInactive
456604829
134356622
BRD-K69099108-001-01-4
S
Image ml316fu50.jpg
>100inactiveinactiveInactive
556604856
134356646
BRD-K54655126-001-01-8
S
Image ml316fu51.jpg
5.9inactiveinactiveInactive
656604841
134356648
BRD-K28436532-001-01-4
S
Image ml316fu52.jpg
>100inactiveinactiveInactive
756604862
134356631
BRD-K16604305-001-01-6
S
Image ml316fu53.jpg
43inactiveinactiveInactive
8823120
134356621
BRD-K77788822-001-01-7
S
Image ml316fu54.jpg
79inactiveinactiveInactive
956604820
134356637
BRD-K41378710-001-01-5
S
Image ml316fu55.jpg
32inactiveinactiveInactive
1014297244
134356660
BRD-K97666538-001-01-6
S
Image ml316fu56.jpg
>100inactiveinactiveInactive
1156604885
134356641
BRD-K48843907-001-01-4
S
Image ml316fu57.jpg
>100inactiveinactiveInactive
1256604876
134356668
BRD-K01920745-001-01-1
S
Image ml316fu58.jpg
72inactiveinactive32.6
1356604811
134356643
BRD-K83470897-001-01-4
S
Image ml316fu59.jpg
62inactiveinactiveInactive
1456604879
134356651
BRD-K33397992-001-01-4
S
Image ml316fu60.jpg
55inactiveinactiveInactive
1556604844
134356645
BRD-K10211459-001-01-0
S
Image ml316fu61.jpg
<1.0inactiveinactive20.7
16759335
134356627
BRD-K28884125-001-01-8
S
Image ml316fu62.jpg
>100inactiveinactiveInactive
*

P = purchased; S = synthesized

Inactive compounds showed no significant activity when tested below 26 μM.

n = number of independent experiments, performed in duplicate

From: Probing Metabolic Requirements for Fungal Virulence — Probe 1

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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