Table 1Inhibitors of NS3 helicase known at the time of grant award

EntryCIDNameStructurePotency IC50 (μM)*
SIDNS3 helicase (literature)NS3 helicase (assay provider lab)
1Not assigned in PubChemQU663
Image ml283fu2.jpg
75>100
216944,5,6,7-tetetrbromo-benzotriazole
Image ml283fu3.jpg
60>100
multiple
3Not assigned in PubChemNS3pepRRGRTGRGRRGLYR0.70.1
*

IC50 values unless otherwise noted.

IC50 value is using the 1b(con1) genotype.

From: Hepatitis C Virus NS3 Helicase Inhibitor Discovery

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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