Figure 9. Effects primuline and its components on HCV helicase catalyzed DNA unwinding.

Figure 9Effects primuline and its components on HCV helicase catalyzed DNA unwinding

(A) MBHAs performed at various concentrations of primuline (CID 415713). Reactions were initiated by adding ATP at the indicated time. (B) Initial rates of DNA unwinding in MBHAs containing indicated concentrations of primuline (CID 415713) (*), compound P1 (CID 44251427) (circles), P2 (CID 44251428) (squares), P3 (CID 44251436) (triangles), or P4 (CID 44251437) (diamonds). Data are fit to Eq. 3 (methods). IC50’s listed in Table 5 are the averages from three separate titrations with each compound.

From: Hepatitis C Virus NS3 Helicase Inhibitor Discovery

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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