Figure 3. Human M4 PAM CRCs of ML293.

Figure 3Human M4 PAM CRCs of ML293

ML253 had an EC50 of 1.3 μM (65% ACh Max) for human M4.

From: Discovery of a novel structural class of M4 positive allosteric modulators: Characterization of ML293, N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicotinamide, with CNS exposure in rats

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.