Table 1Summary of Assays

PubChem AIDTypeTargetConc. RangeSamples TestedNotes
AID 2101Primary qHTSN370S GC57.5 μM – 0.7 nM326,770Tissue, blue
AID 2590ConfirmatoryN370S GC54 μM – 0.01 nM320Tissue, blue
AID 2613SecondaryN370S GC57.5 μM – 0.3 nM83Tissue, red
AID 2592SecondaryWildtype GC57.5 μM – 0.3 nM21Tissue, blue
AID 2588SecondaryWildtype GC50 μM – 0.1 nM152Tissue, red
AID 2595SecondaryWildtype GC77 μM – 0.3 nM52Purified, blue
AID 2597SecondaryN370S GC77 μM – 0.3 nM52Purified, blue
AID 2596SecondaryN370S GC230 μM – 0.1 nM94Purified, natural substrate
AID 2577Anti-targetAlpha-glucosidase57.5 μM – 0.3 nM70Purified, blue
AID 2578Anti-targetAlpha-galactosidase57.5 μM – 0.3 nM70Purified, blue
AID 2587TertiaryN370S GC100 μM – 10 nM4Immunostaining of fibroblast lysosomes
AID 2589TertiaryWildtype GC100 μM – 10 nM4Immunostaining of fibroblast lysosomes
AID 2593SummaryN370S GC

From: Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase

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