Table 1Assay Summaries

AIDName of AssayTested/ActiveNon-ML TestedPurchased Tested/ActiveSynthesized Tested/Active
AID 2139Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR).N/AN/AN/AN/A
AID 463078Late stage assay provider results from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): luminescent-based assay to identify RORα inhibitors6/1606/1
AID 463143Late stage assay provider counterscreen from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): luminescence-based cell-based assay to identify activators of the liver X receptor (LXR)6/0606/0
AID 463144Late stage assay provider counterscreen from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): luminescence-based cell-based assay to identify inhibitors of glucose-6-phosphatase (G6PC)1/1101/1
AID 463145Late stage assay provider counterscreen from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): luminescence-based cell-based assay to identify activators of the farnesoid X receptor (FXR)6/0606/0
AID 463147Late stage assay provider counterscreen from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): luminescence-based cell-based assay to identify RORγ inhibitors6/0606/0
AID 463148Late stage assay provider counterscreen from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): luminescence-based cell-based assay to identify inhibitors of the human herpes virus VP16 transcriptional activator protein (VP16)6/1606/1
AID 463150Late stage assay provider counterscreen from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): luminescence-based dose response assay to identify activators of the liver X receptor (LXR)1/0101/0
AID 463151Late stage assay provider counterscreen from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): luminescent-based dose response assay to identify RORγ inhibitors1/0101/0
AID 463152Late stage assay provider results from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): luminescence-based dose response assay to identify RORα inhibitors1/1101/1
AID 463172Late stage assay provider counterscreen from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): luminescence-based cell-based dose response assay to identify inhibitors of glucose-6-phosphatase (G6PC).1/1101/1
AID 504906Late stage assay provider results from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): radioligand binding assay for RORα using [3H]25-hydroxycholesterol to determine whether probe candidates bind directly to RORα.1/11/101/1
AID 504907Late stage assay provider results from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): fluorescence-based real-time polymerase chain reaction assay to determine the effect of probe candidates on endogenous expression of glucose-6-phosphatase (G6PC).1/11/101/1
AID 504899Late stage assay provider results from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORα): Diet-Induced obesity (DIO) mouse model studies to assess the effect of probe candidate on hepatic glucose production.1/11/101/1

From: Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORĪ±)

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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