Table 48Description of the scales and subscales evaluated in trials included in this review

FACT Instrument or Subscale#Trials ReportingType of InstrumentDomains Addressed (#Questions)Range of Scale (Highest=Most Favorable)
FACT-fatigue subscale20 (14 with complete data)Symptom-specificFatigue-specific questions from anemia-specific questions of FACT-An (13)0–52
FACT non-fatigue anemia subscale8Symptom-specificQuestions from the anemia-specific questions of FACT-An that are not part of the FACT-fatigue subscale (7)0–28
FACT-An(emia)7Symptom-specificIncludes FACT-G, all domains (27)a
Anemia-specific symptoms (20)
FACT-G(eneral)6GeneralPhysical well-being (7)
Social/family well-being (7)
Emotional well-being (6)
Functional well-being (7)
SF-36 Physical Summary Component (PCS) score2GeneralPhysical Functioning (10)
Role Physical (4)
Bodily Pain (2)
(these scales contribute most to PSC scoring)
Transformed to mean of 50 and SD of 10 in the US population
EORTC QLQ-C30 core questionnaire2General5 functional domains
3 symptom scales
single items for symptoms
2 global items
Transformed to 0–100
SF-36 Mental Summary Component (MCS) score1GeneralVitality (4)
Social functioning (2)
Role-emotional (3)
Mental health (5)
Transformed to mean 50 and SD 10 in the US population
Nottingham Health Profile1GeneralPart I, 38 questions in 6 subareas:
  • energy level (3)
  • pain (8)
  • emotional reaction (9)
  • sleep (5)
  • social isolation (5)
  • physical abilities (8)
Part II, 7 life areas affected (7)
Part I:0–100

Part II: 0–7
Symptom Distress Scale1GeneralNausea frequency, nausea severity, appetite, insomnia, pain frequency, pain severity, fatigue, bowel pattern, concentration, appearance, breathing, outlook, and cough (13)Transformed to 0–100
PedsQL-GCS1GeneralPhysical functioning (8)
Emotional functioning (5)
Social functioning (5)
School functioning (5)
Transformed to 0–100
PedsQL 3.0 Cancer Module1Symptom-specificPain and hurt (2)
Nausea (5)
Procedural anxiety (3)
Treatment anxiety (3)
Worry (3)
Cognitive problems (5)
Perceived physical appearance (3)
Communication (3)
Transformed to 0–100
Lung Cancer Symptom Scale1Symptom/Disease-specificPatient scale: Symptoms, total symptomatic distress, activity status, overall quality of life

Observer scale: Symptoms
VAS 0 (severe) to 100
Patient: 9 scales
Observer: 6 scales

EORTC QLQ-C30 = ; FACT = Functional Assessment of Cancer Therapy; PedsQL-GCS = Pediatric Quality of Life Inventory-Generic Core Scale; SD = standard deviation


While FACT-Anemia incorporates FACT-G, it was not classified as a general instrument since the results could be dominated by either the general FACT-G or the symptom-specific subscales.

From: Results

Cover of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment
Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment: Comparative Effectiveness Update [Internet].
Comparative Effectiveness Reviews, No. 113.
Grant MD, Piper M, Bohlius J, et al.

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