Appendix Table F1Changes in trials included in current and 2006 reviews

TrialsHematologic Response Study
Darbepoetin vs. EpoetinExcluded2Glaspy 2003, Alexopoulos 2004
Included unchanged2Glaspy 2002, Waltzman 2005
Data updated0
New data
Total Studies Included0
Epoetin vs. ControlExcluded2Cazzola 1995, Osterborg 1996
Included unchanged12Bamias 2003, Boogaerts 2003, Case 1993, Chang 2005, Dammacco 2001, Henry 1995, Iconomou 2003, Littlewood 2001, Oberhoff 1998, Osterborg 2002, Rose 1994, Witzig 2005
Data updated1
New data3Razzouk 2006, Aapro 2008, ML17620
Total Studies Included16
Darbepoetin vs. ControlExcluded1Hedenus 2002
Included unchanged2Hedenus 2003, Kotasek 2003
Data updated0
New data0
Total Studies Included2
TrialsTransfusion Rates Study
Darbepoetin vs. EpoetinExcluded1Alexopoulos 2004
Included unchanged2Glaspy 2002, Schwartzberg 2004
Data updated2Glaspy 2005 → Glaspy 2006, Waltzman 2005 → Waltzman 2005
New data1Kotsori 2006
Total Studies Included5
Epoetin vs. ControlExcluded18Aravantinos 2003, Carabantes 1999, Cascinu 1994, Cazzola 1995, Del Mastro 1997, Dunphy 1999, Henze 2002, Huddart 2002, Kunikane 2001, Kurz 1997, Osterborg 1996, Quirt 1996, Ten Bokkel Huinink 1998, Thatcher 1999, Throuvalas 2000, Vadhan-Raj 2004, Welch 1995, Wurnig 1996
Included unchanged13Bamias 2003, Boogaerts 2003, Case 1993, Chang 2005, Dammacco 2001, Henry 1995, Iconomou 2003, Littlewood 2001, Oberhoff 1998, Osterborg 2002, Thomas 2002, Rose 1994, Witzig 2005
Data updated3Razzouk 2004 → Razzouk 2006, Janinis 2003→ Christodoulou 2009, Savonije 2004→Savonije 2005
New data15Aapro 2008, Blohmer 2004, EPO-INT-3, Fujisaka 2011, Goss 2005, Grote 2005, Gupta 2009, Leyland-Jones 2005, Milroy 2011, Moebus 2007, Porter 1996, Pronzato 2010, Ray-Coquard 2009, Tsuboi 2009, Wilkinson 2006
Total Studies Included28
Darbepoetin vs. ControlExcluded1Hedenus 2002
Included unchanged3Hedenus 2003, Kotasek 2003, Vansteenkiste 2002
Data updated0
New data4Hernandez 2009, Katakami 2008, Pirker 2008, Untch 2011
Total Studies Included7
TrialsOverall Survival Study
Darbepoetin vs. EpoetinExcluded1Waltzman 2005 (abstract)→ Waltzman 2005 (included in on-study mortality)
Included unchanged0
Data updated0
New data0
Total Studies Included2
Epoetin vs. ControlExcluded13Cascinu 1994, Cazzola 1995, Del Mastro 1997, Dunphy 1999, EPO-CAN-20, Kurz 1997, O’Shaughnessy 2005, Osterborg 1996, P-174, ten Bokkel 1998, Thatcher 1999, Throuvalas 2000, Vadhan-Raj 2004
Included unchanged1Bamias 2003
Data updated21Case 1993 → Case 1993 IPD, Chang 2005 → Chang 2005 IPD, Coiffier 2001 → Boogaerts 2003 IPD, Dammacco 2001 → Dammacco 2001 IPD, Henke 2003 → Henke 2003 IPD, Henry 1995 → Henry 1995 IPD, Leyland-Jones 2003 → Leyland-Jones 2005 IPD, Littlewood 2001 → Littlewood 2001 IPD, Machtay 2004 → Machtay 2007, Oberhoff 1998 → Oberhoff 1998 IPD, Osterborg 2005 → Osterborg 2002 IPD, Rose 1994 → Rose 1994 IPD, Savonije 2004 → Savonije 2005 IPD, Witzig 2005 → Witzig 2005 IPD, EPO-CAN-15 → Goss 2005 IPD, EPO GBR-07 → Hoskin 2009 IPD, GOG-191 → Thomas 2008, N93004 2004 → Grote 2005 IPD, INT-1 → EPO-INT-1IPD, INT-3 → EPO-INT-3 IPD
New data16Aapro 2008 IPD, Fujisaka 2011, Pronzato 2002 IPD, Ray-Coquard 2009 IPD, Thomas 2002 IPD, Wilkinson 2006 IPD, Milroy 2003 IPD, Moebus 2007 IPD, Debus 2006 IPD, Antonadou 2001, Blohmer 2004, Christodoulou 2009, Gupta 2009, Tsuboi 2009, Engert 2009, ML17620
Total Studies Included38
Darbepoetin vs. ControlExcluded1Hedenus 2002
Included unchanged4Hedenus 2003, Kotasek 2003, Vansteenkiste 2002
Data updated0
New data4Hernandez 2009, Pirker 2008, Overgaard 2009, Untch 2011
Total Studies Included8
TrialsThromboembolic Events Study
Darbepoetin vs. EpoetinExcluded0
Included unchanged1Schwartzberg 2004
Data updated2Glaspy 2005 → Glaspy 2006, Waltzman 2005 → Waltzman 2005
New data0
Total Studies Included3
Epoetin vs. ControlExcluded10Cascinu 1994, Osterborg 1996, P-174, Rosenzweig 2004, Ten Bokkel 1998, Thatcher 1999, Throuvalas 2000, Vadhan-Raj 2004, Welch 1995, EPO-CAN-20
Included unchanged13Bamias 2003, Case J&J 2004, Chang 2005, Dammacco J&J 2004, EPO-INT-1 J&J 2004, EPO-INT-3 J&J 2004, Henke Roche 2004, Henry J&J 2004, Leyland-Jones J&J 2004, Littlewood J&J 2004, Osterborg 2002, Rose J&J 2004, Witzig J&J 2004
Data updated7EPO-CAN-15 → Goss 2005, N93004 2004 → Grote 2005, EPO-GBR-07 → Hoskin 2009, GOG 191 → Thomas 2008, Machtay 2004 → Machtay 2007, Savonije 2004→ Savonije 2005, Razzouk 2004 → Razzouk 2006
New data12Aapro 2008, Blohmer 2011, J&J 2004, Debus 2006, J&J 2007, Engert 2009; Fujisaka 2011, Gupta 2009, Milroy 2011, Moebus 2007, Pronzato 2010, Ray-Coquard 2009, Tsuboi 2009, Wilkinson 2006
Total Studies Included32
Darbepoetin vs. ControlExcluded
Included unchanged1Vansteenkiste 2002
Data updated
New data5Hedenus 2003, Hernandez 2009, Pirker 2008, Overgaard 2009, Untch 2011
Total Studies Included6
TrialsQoL FACT-Fatigue (Complete Data) Study
Darbepoetin vs. EpoetinExcluded0
Included unchanged0
Data updated1Glaspy 2005 → Glaspy 2006
New data0
Total Studies Included1
Epoetin vs. ControlExcluded0
Included unchanged7Boogaerts 2003, Chang 2005, Hedenus 2003, Iconomou 2003, Littlewood 2001, Osterborg 2002, Witzig 2005
Data updated0
New data4Christodoulou 2009, Hoskin 2009, Savonije 2005, Tsuboi 2009
Total Studies Included11
Darbepoetin vs. ControlExcluded0
Included unchanged1Vansteenkiste 2002
Data updated0
New data2Kotasek 2003, Pirker 2008
Total Studies Included3
TrialsTumor Response Study
Darbepoetin vs. EpoetinExcluded0
Included unchanged0
Data updated0
New data0
Total Studies Included0
Epoetin vs. ControlExcluded3Throuvalas 2000, N93004 2004, Vadhan-Raj 2004
Included unchanged1Henke 2003
Data updated4EPO-CAN-15 → Goss 2005, EPO-GBR-07 → Hoskin 2009, GOG 191 → Thomas 2008, Machtay 2004 → Machtay 2007
New data8Blohmer 2011, Debus 2006, Engert 2009, Gupta 2009, Milroy 2011, Moebus 2007, Pronzato 2010, Wagner 2004
Total Studies Included13
Darbepoetin vs. ControlExcluded0
Included unchanged0
Data updated0
New data2Overgaard 2009, Untch 2011
Total Studies Included2
TrialsADE (Hypertension) Study
Darbepoetin vs. EpoetinExcluded0
Included unchanged0
Data updated0
New data0
Total Studies Included0
Epoetin vs. ControlExcluded9Cascinu 1994, Kunikane 2001, Osterborg 1996, Rosenzweig 2004, Silvestris 1995, Ten Bokkel Huinink 1998, Thatcher 1999, Welch 1995
Included unchanged7Bamias 2003, Case 1993, Dammaccco 2001, Henry 1995, Iconomou 2003,a Littlewood 2001, Rose 1994
Data updated0
New data8Fujisaka 2011, Hoskin 2009, Milroy 2011, Osterborg 2002, Razzouk 2006, Savonije 2005, Wilkinson 2006, Tsuboi 2009
Total Studies Included15
Darbepoetin vs. ControlExcluded0
Included unchanged1Vansteenkiste 2002
Data updated0
New data2Hernandez 2009, Pirker 2008
Total Studies Included3
TrialsADE (Thrombocytopenia/Hemorrhage) Study
Darbepoetin vs. EpoetinExcluded0
Included unchanged0
Data updated0
New data1Pirker 2008
Total Studies Included1
Epoetin vs. ControlExcluded4Cascinu 1994, Del Mastro 1997, Kunikane 2001, Thatcher 1999
Included unchanged3Bamias 2003, Boogaerts 2003, Dammacco 2001
Data updated0
New data7aFujisaka 2011, Goss 2005, Littlewood 2001, Milroy 2010, Savonije 2005, Tsuboi 2009, Witzig 2005
Total Studies Included12
Darbepoetin vs. ControlExcluded0
Included unchanged0
Data updated0
New data2Pirker 2008, Untch 2011
Total Studies Included2
TrialsADE (Rash) Study
Darbepoetin vs. EpoetinExcluded0
Included unchanged0
Data updated0
New data0
Total Studies Included0
Epoetin vs. ControlExcluded5Del Mastro 1997, Kurz 1997, Osterborg 1996, Thatcher 1999, Welch 1995
Included unchanged1Henry 1995
Data updated0
New data5Gupta 2009, Milroy 2011, Osterborg 2002, Tsuboi 2009, Witzig 2005
Total Studies Included6
Darbepoetin vs. ControlExcluded0
Included unchanged0
Data updated0
New data0
Total Studies Included0
TrialsADE (Seizure) Study
Darbepoetin vs. EpoetinExcluded1Glaspy 2003
Included unchanged0
Data updated0
New data0
Total Studies Included0
Epoetin vs. ControlExcluded1Cascinu 1994
Included unchanged2Case 1993, Henry 1995
Data updated0
New data1Savonije 2005
Total Studies Included3
Darbepoetin vs. ControlExcluded0
Included unchanged0
Data updated0
New data2Hernandez 2009, Pirker 2008
Total Studies Included2
TrialsADE (Antibodies) Study
Darbepoetin vs. EpoetinExcluded1Glaspy 2003
Included unchanged2Schwartzberg 2004, Glaspy 2002
Data updated1Glaspy 2005 → Glaspy 2006
New data1Waltzman 2005
Total Studies Included4
Epoetin vs. ControlExcluded2Thatcher 1999, Ten Bokkel 1998
Included unchanged4Chang 2005, Henry 1995, Oberhoff 1998, Osterborg 2002
Data updated0
New data1Tsuboi 2009
Total Studies Included5
Darbepoetin vs. ControlExcluded0
Included unchanged1Vansteenkiste 2002
Data updated0
New data4Hedenus 2003, Hernandez 2009, Kotasek 2003, Pirker 2008
Total Studies Included5
a

No events

a

Gupta 2009 also reported thrombocytopenia but without consistent event frequency so not included in results.

From: Appendix F, Changes in Trials Included in Current and 2006 Reviews

Cover of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment
Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment: Comparative Effectiveness Update [Internet].
Comparative Effectiveness Reviews, No. 113.
Grant MD, Piper M, Bohlius J, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.