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Treatment of Tuberculosis: Guidelines. 4th edition. Geneva: World Health Organization; 2010.

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Treatment of Tuberculosis: Guidelines. 4th edition.

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A3TB treatment outcomes

For the meeting in October 2008, members of the Guidelines Group scored the TB treatment outcomes that they considered to be the most critical for the choice of TB treatment regimens. They were asked to take the point of view of NTP managers – the target audience for this publication. Of the 19 members who attended that meeting, 15 (79%) responded; the results are shown below.

ScoreRelative importance
1–3Not important for making recommendations on TB regimen
4–6Important but not critical for making recommendations on TB regimen
7–9Critical for making recommendations on TB regimen

What are the most important beneficial outcomes to consider when making decisions on TB treatment regimens?

OutcomesRelative importance
Reducing emergence of MDR-TB, prevent drug resistance8
Survival8
Staying disease-free (avoiding relapse)8
Halting transmission of TB, a TB-free community8
Bacteriological cure6
Negative sputum smears at 2 months6
Relief of TB symptoms5
Cost savings5

What are the most significant risks to consider when making decisions on TB treatment regimens?

OutcomesRelative importance
Acquired drug resistance8
Failure8
Relapse8
Infecting health care workers and the community7
Default7
Loss of efficacy of HIV medicines due to poorly managed drug interactions7
Drug toxicity7
Interaction with non-TB medications6
Financial burden5
Copyright © 2010, World Health Organization.

All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel: +41 22 791 4857; e-mail: tni.ohw@sredrokoob). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: tni.ohw@snoissimrep).

Bookshelf ID: NBK138740

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