Figure 5. . Budded virus infection of a Group I virus.

Figure 5.

Budded virus infection of a Group I virus. BV attach to receptors located in clathrin coated pits via GP64 and are endocytosed (A). The endocytic vesicle is acidified and this changes the conformation of GP64 and causes the virion envelope to fuse with the endosomal membrane releasing the nucleocapsid into the cytoplasm (B). The nucleocapsid enters the nucleus through a nuclear pore complex (C), genes are transcribed, DNA is replicated and nucleocapsids are assembled in the virogenic stroma (D). In Group I virus, at least two envelope proteins are synthesized, GP64 and F. They are likely translated in association with the endoplasmic reticulum, glycosylated and transported to and incorporated into the cytoplasmic membrane via the Golgi apparatus (E). Nucleocapsids destined to become BV exit the nucleus and are thought to transiently obtain an envelope that is lost (F). Evidence suggests that they exit the cell by association with the motor protein kinesin that moves along microtubules (F) (36). Upon reaching the F- and GP64-modified cytoplasmic membrane, they bud through, and obtain envelopes (G).

From: Chapter 3, The baculovirus replication cycle: Effects on cells and insects

Cover of Baculovirus Molecular Biology
Baculovirus Molecular Biology [Internet]. 3rd edition.
Rohrmann GF.
Bethesda (MD): National Center for Biotechnology Information (US); 2013.
Copyright © 2013, George Rohrmann.

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