Figure F-157 is titled “Rate of headache for SSRIs compared with placebo.” The figure displays a forest plot reporting the risk difference of headache stratified by fluoxetine compared with placebo and sertraline compared with placebo. The forest plot depicts that a higher rate of headaches occurred among patients treated with fluoxetine (4 trials, risk difference 0.03, 95% CI −0.04 to 0.09, I2 = 28.2%) and sertraline (6 trials, risk difference 0.03, 95% CI −0.03 to 0.08, I2 = 0.0%). Overall there was a 3% higher rate of headache related to SSRIs than placebo (risk difference 0.03, 95% CI −0.01 to 0.06, I2 = 1.7%).

Figure F-157Rate of headache for SSRIs compared with placebo

Timing of outcome assessment: 10 weeks (Panahi, 2011, Zohar, 2002), 12 weeks (Martenyi, 2007; Martenyi 2006; Davidson, 2006; Davidson, 2001; Brady, 2000; Friedman, 2007), 5 weeks (van der Kolk, 1994).

From: Appendix F, Meta-Analysis

Cover of Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD)
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