Figure F-112 is titled “Change in HAM-D for SSRIs compared with placebo.” The figure displays a forest plot reporting the weighted mean difference in HAM-D scores for sertraline compared with placebo. This figure is described further in the “Prevention or reduction of comorbid medical or psychiatric conditions” section as follows: “For sertraline, data was available for meta-analysis of five trials reporting the HAM-D. Our meta-analysis found no statistically significant difference between sertraline and placebo (HAM-D, mean change from baseline: weighted mean difference −0.77; 95% CI −2.1 to 0.55; I2=25%, 5 trials, N=1,010). Data trended in favor of sertraline for three of the individual trials; it favored placebo for the other two.”

Figure F-112Change in HAM-D for SSRIs compared with placebo

Timing of outcome assessment: 12 weeks for all included studies.

From: Appendix F, Meta-Analysis

Cover of Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD)
Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD) [Internet].
Comparative Effectiveness Reviews, No. 92.
Jonas DE, Cusack K, Forneris CA, et al.

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