Table 11Calculated Property Comparison of ML213 with MDDR Compounds

PropertyML213, CID3111211MDDR Phase IMDDR Launched
MW257.4438.98415.20
cLogP4.113.212.21
TPSA29.197.0691.78
Hdon12.122.13
Hacc17.066.47
LogS−4.23−4.96−3.73
NrotB27.085.71

From: A small molecule activator of KCNQ2 and KCNQ4 channels

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