Table 1Calculated Property Comparison with MDDR Compounds

PropertyCID 46926631 (ML227)MDDR Phase IMDDR Launched
MW418.57438.98415.20
cLogP5.193.212.21
TPSA56.4997.0691.78
HBD1.002.122.13
HBA4.007.066.47
LogS−5.87−4.96−3.73
NrotB9.007.085.71

From: Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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