Figure 4. Dose Response Curves for Initial Hit, MLS001217863.

Figure 4Dose Response Curves for Initial Hit, MLS001217863

MLS001217863 (SID 49678600, CID 24761960) was used over a range of concentrations up to 35 μM in the primary assay and several secondary assays. Dose curves were generated with Genedata Condeseo and show normalized percent activity for the individual doses. DiI-HDL Uptake (AID 540354), IC50= 0.035 μM (A); Alexa 488 HDL binding (AID 588810), AC50=0.282 μM (B); 3h CellTiter-Glo (AID 588830), AC50>35 μM (C) and 24h CellTiter-Glo (AID 540246), IC50 >35 μM (D). =replicate 1, △=replicate 2

From: A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 1

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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