Table 17Comparison of the Probe to Project Criteria

No.PropertyCPDP RequirementProbe
1STK33 inhibitorIC50 < 500 nM250 nM
2Selectivity for STK33 vs PKA>10-fold> 40-fold
3Selectivity for STK33 vs Aurora B>10-fold> 40-fold

From: Screen for Inhibitors of STK33 Kinase Activity

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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