Table 16Selectivity Data Versus Aurora B for Selected Quinoxalinone Analogs

Entry No.CID
SID
Broad ID
*
Image ml281fu89.jpg
Potency (μM)
Mean ± S.E.M.
(n=replicates)
Fold Selectivity
STK33Aurora B
R1R2nIC50nIC50
13163413
125299372
BRD-K86755954
S
Image ml281fu90.jpg
4-Cl30.16 ± 0.031> 10> 60
25337742
125299375
BRD-K20154023
S
Image ml281fu90.jpg
4-F30.41 ± 0.031> 10> 20
353377438
125299373
BRD-K11118992
S
Image ml281fu90.jpg
4-OMe30.25 ± 0.031> 10> 40
453377429
125299374
BRD-K79661811
S
Image ml281fu90.jpg
4-OCF330.11 ± 0.011> 10> 90
553377448
125299367
BRD-K48188942
S
Image ml281fu90.jpg
4-iPr30.014 ± 0.00617.8550
653377411
125299378
BRD-K09265391
S
Image ml281fu90.jpg
5-Cl30.27 ± 0.051> 10> 35
753377419
125299379
BRD-K66645150
S
Image ml281fu90.jpg
5-F30.078 ± 0.0181> 10> 130
83162043
99351038, 125081988
BRD-K91863345
S
Image ml281fu90.jpg
H30.28 ± 0.031> 10> 35
953347979
125081982
BRD-K05922103
S
Image ml281fu91.jpg
H30.076 ± 0.0061> 10> 130
1053347999
125081977
BRD-K51962689
S
Image ml281fu92.jpg
H30.58 ± 0.021> 10> 15
117186158
125081981
BRD-K30634593
S
Image ml281fu93.jpg
H30.15 ± 0.021> 10> 65
125019834
125081983
BRD-K82654216
S
Image ml281fu94.jpg
H30.98 ± 0.181> 10> 10
*

P=purchased; S=synthesized

From: Screen for Inhibitors of STK33 Kinase Activity

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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