Table G2Cognitive therapy compared with an inactive comparator (waitlist)

Outcome: Number of Studies; Number of Subjects; DesignRisk of BiasConsistencyDirectnessPrecisionMagnitude of Effect: Summary Effect Size (95% CI)Strength of Evidence
Incidence of PTSD at end of treatment: 1; 60; RCTLowUnknown, single studyDirectImprecisebCT vs. WL, CAPS-2, 63% vs. 77%, p=NRInsufficient
Incidence of PTSD at 5 months: 1; 112; RCTMediumaUnknown, single studyDirectImprecisebCT vs. WL, CAPS, 20.0% vs. 58.7%, p=0.002Insufficient
PTSD symptom severity at end of treatment: 1; 60; RCTLowUnknown, single studyDirectImprecisebCT vs. WL, CAPS-2 total, 43.0 vs. 55.9, p=NR; IES-I, 17.7 vs. 22.1, p=NR; IES-A, 17.1 vs. 22.6, p=NRInsufficient
PTSD symptom severity at 5 months: 1; 112; RCTMediumaUnknown, single studyDirectImprecisebCT vs. WL, CAPS total, 29.5 vs. 50.6, p=NR; CAPS re-experiencing, 6.9 vs. 11.8, p=NR; CAPS avoidance, 12.1 vs. 22.3, p=NR; CAPS hyperarousal, 10.5 vs. 16.5, p=NR; PSS-SR total, 11.6 vs. 22.1, p=NRInsufficient
Depression symptom severity at end of treatment: 1; 60; RCTLowUnknown, single studyDirectImprecisebCT vs. WL, BDI-2, 18.9 vs. 21.9; p=NSInsufficient
Anxiety symptom severity at end of treatment: 1; 60; RCTLowUnknown, single studyDirectImprecisebCT vs. WL, BAI, 23.4 vs. 19.6, p=NSInsufficient
Incidence/severity of comorbid conditions: 0; 0NANANANANAInsufficient
Quality of Life: 0; 0NANANANANAInsufficient
Return to work/return to active duty or ability to work: 0; 0NANANANANAInsufficient
Incidence of self-injurious or suicidal thoughts, attempts, or behaviors (including suicide): 0; 0NANANANANAInsufficient
Incidence of aggressive or homicidal thoughts, attempts, or behaviors (including homicide) 0; 0NANANANANAInsufficient
Perceived utility: 0; 0NANANANANAInsufficient
a

No ITT; completer analysis of 133 randomized participants

b

Small sample size (< 300 observations)

Abbreviations: BAI = Beck Anxiety Inventory; BDI-2 = Beck Depression Inventory-2; CAPS/CAPS-2 = Clinician Administered PTSD Scale/Clinician Administered PTSD Scale-2; CI = confidence interval; CT = Cognitive therapy; IES-A = Impact of Event-Avoidance subscale; IES-I = Impact of Event-Intrusion subscale; ITT = intent to treat analysis; NA = not applicable; NR = not reported; NS = not significant; PSS-SR = PTSD Symptom Scale-Self Report; PTSD = posttraumatic stress disorder; RCT = randomized controlled trial; WL = Waitlist

From: Appendix G, Psychological, Pharmacological, and Emerging Interventions: Strength-of-Evidence Grades

Cover of Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma
Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma [Internet].
Comparative Effectiveness Reviews, No. 109.
Gartlehner G, Forneris CA, Brownley KA, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.