Table G14Cognitive behavioral therapy + hypnosis compared with supportive counseling

Outcome: Number of Studies; Number of Subjects; DesignRisk of BiasConsistencyDirectnessPrecisionMagnitude of Effect: Summary Effect Size (95% CI)Strength of Evidence
Incidence of PTSD at end of treatment: 1; 54; RCTMediumaUnknown, single studyDirectImprecisebCBT+Hypnosis vs. SC, CAPS-2, 30% vs. 50%, p=NRInsufficient
Incidence of PTSD at 6 months: 1; 54; RCTMediumaUnknown, single studyDirectImprecisebCBT+Hypnosis vs. SC, CAPS-2, 40% vs. 58%, p=NRInsufficient
PTSD symptom severity at end of treatment: 1; 54; RCTMediumaUnknown, single studyDirectImprecisebCBT+Hypnosis vs. SC, IES-I, 11.30 vs. 19.83, p<0.05Insufficient
PTSD symptom severity at 6 months: 1; 54; RCTMediumaUnknown, single studyDirectImprecisebCBT+Hypnosis vs. SC, IES-I, 13.57 vs. 20.21, p<0.05Insufficient
Severity of depressive symptoms at end of treatment: 1; 54; RCTMediumaUnknown, single studyDirectImprecisebCBT+Hypnosis vs. SC, BDI-2, 11.37 vs. 14.96, p=NRInsufficient
Severity of depressive symptoms at 6 months: 1; 54; RCTMediumaUnknown, single studyDirectImprecisebCBT+Hypnosis vs. SC, BDI-2, 13.57 vs. 16.29, p=NRInsufficient
Severity of anxiety symptoms at end of treatment: 1; 54; RCTMediumaUnknown, single studyDirectImprecisebCBT+Hypnosis vs. SC, BAI, 15.47 vs. 20.25, p=NRInsufficient
Severity of anxiety symptoms at 6 months: 1; 54; RCTMediumaUnknown, single studyDirectImprecisebCBT+Hypnosis vs. SC, BAI, 17.07 vs. 21.13, p=NRInsufficient
Incidence/severity of comorbid conditions: 0; 0NANANANANANA
Quality of Life: 0; 0NANANANANAInsufficient
Return to work/return to active duty or ability to work: 0; 0NANANANANAInsufficient
Incidence of self-injurious or suicidal thoughts, attempts, or behaviors (including suicide): 0; 0NANANANANAInsufficient
Incidence of aggressive or homicidal thoughts, attempts, or behaviors (including homicide): 0; 0NANANANANAInsufficient
Perceived utility: 0; 0NANANANANAInsufficient
a

High (> 20%) overall attrition; high (> 15%) differential attrition between groups; no data reported on # of sessions completed per group

b

Small sample size (< 300 observations)

Abbreviations: BAI = Beck Anxiety Inventory; BDI-2 = Beck Depression Inventory-2; CAPS-2 = Clinician Administered PTSD Scale-2; CBT = Cognitive behavioral therapy; CBT+Hypnosis = CBT combined with hypnosis; CI = confidence interval; IES-I = Impact of Event Scale - Intrusion subscale; NA = not applicable; NR = not reported; PTSD = posttraumatic stress disorder; RCT = randomized controlled trial; SC = Supportive counseling

From: Appendix G, Psychological, Pharmacological, and Emerging Interventions: Strength-of-Evidence Grades

Cover of Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma
Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma [Internet].
Comparative Effectiveness Reviews, No. 109.
Gartlehner G, Forneris CA, Brownley KA, et al.

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