Table 26Body of evidence for sublingual immunotherapy affecting asthma and/or rhinitis/or rhinoconjunctivitis symptoms

StudyAllergenComparatorsNumber of ParticipantsRisk of BiasDirection of ChangeDirectnessMagnitude of Effect
Pozzan 2010169AlternariaSLIT
Placebo
52Medium+DirectCould not determine*
Marogna 2005146BirchSLIT
Placebo
79Medium+DirectModerate
Bush 2011156Dust mitehigh dose
low dose
Placebo
31MediumNRDirectCould not determine*
Valovirta 2006168
Savolainen 2006175
Tree mixhigh dose
low dose
Placebo
98MediumHigh dose +

Low dose +
DirectHigh dose: Strong

Low dose: Moderate
Marogna 2006147Birch and GrassSLIT birch
SLIT grass
SLIT birch+grass
Pharmacotherapy
48Medium+DirectStrong

+ = positive; NR = not reported; SLIT = sublingual immunotherapy

*

Data provided in the article was not enough to calculate the magnitude of effect.

From: Results

Cover of Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma: Comparative Effectiveness Review
Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma: Comparative Effectiveness Review [Internet].
Comparative Effectiveness Reviews, No. 111.
Lin SY, Erekosima N, Suarez-Cuervo C, et al.

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