Table 60Botulinum toxin type A (Botox) (pre vs post treatment) Kidney - Clinical study characteristics and clinical summary of findings

No. of studiesDesignTreatment (n)Control (n)ResultsLimitationsInconsistencyIndirectnessImprecisionOther considerationsQuality
Outcome: Kidney function
1 [A]Prospective observational studyBotulinum toxin type A (Botox)
Mean vesciouteral reflux (VUR) grade Mean Pre-treatment versus 4 months
1.7 versus 0.7; p<0.01
VUR grade decreased in 11 patients (73%)
S (i)NNS (ii)NVery low

S serious N none


Before versus after data.


Small study sample, uncertainty in terms of precision – no information on estimations of effect.


Kajbafzadeh et al. 200679

From: 8, Treatment to improve bladder storage

Cover of Urinary Incontinence in Neurological Disease
Urinary Incontinence in Neurological Disease: Management of Lower Urinary Tract Dysfunction in Neurological Disease.
NICE Clinical Guidelines, No. 148.
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